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Timing of Assessment of Humoral and Cell-Mediated Immunity after Influenza Vaccination.
Otani, Naruhito; Nakajima, Kazuhiko; Yamada, Kumiko; Ishikawa, Kaori; Ichiki, Kaoru; Ueda, Takashi; Takesue, Yoshio; Yamamoto, Takuma; Higasa, Satoshi; Tanimura, Susumu; Inai, Yuta; Okuno, Toshiomi.
Afiliación
  • Otani N; Department of Public Health, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Nakajima K; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Yamada K; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Ishikawa K; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Ichiki K; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Ueda T; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Takesue Y; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Yamamoto T; Department of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Higasa S; Department of Legal Medicine, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Tanimura S; Department of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
  • Inai Y; Department of Public Health Nursing, Mie University Graduate School of Medicine, Tsu 514-0001, Mie, Japan.
  • Okuno T; The Research Foundation for Microbial Diseases of Osaka University, Kanonji 768-0065, Kagawa, Japan.
Vaccines (Basel) ; 12(6)2024 May 27.
Article en En | MEDLINE | ID: mdl-38932313
ABSTRACT
Assessment of the immune response to influenza vaccines should include an assessment of both humoral and cell-mediated immunity. However, there is a lack of consensus regarding the timing of immunological assessment of humoral and cell-mediated immunity after vaccination. Therefore, we investigated the timing of immunological assessments after vaccination using markers of humoral and cell-mediated immunity. In the 2018/2019 influenza season, blood was collected from 29 healthy adults before and after vaccination with a quadrivalent inactivated influenza vaccine, and we performed serial measurements of humoral immunity (hemagglutination inhibition [HAI] and neutralizing antibody [NT]) and cell-mediated immunity (interferon-gamma [IFN-γ]). The HAI and NT titers before and after vaccination were strongly correlated, but no correlation was observed between the markers of cell-mediated and humoral immunity. The geometric mean titer and geometric mean concentration of humoral and cellular immune markers increased within 2 weeks after vaccination and had already declined by 8 weeks. This study suggests that the optimal time to assess the immune response is 2 weeks after vaccination. Appropriately timed immunological assessments can help ensure that vaccination is effective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza