Your browser doesn't support javascript.
loading
Alimentary Treatment with Trehalose in a Pharmacological Model of Alzheimer's Disease in Mice: Effects of Different Dosages and Treatment Regimens.
Pupyshev, Alexander B; Akopyan, Anna A; Tenditnik, Michael V; Ovsyukova, Marina V; Dubrovina, Nina I; Belichenko, Victor M; Korolenko, Tatiana A; Zozulya, Svetlana A; Klyushnik, Tatiana P; Tikhonova, Maria A.
Afiliación
  • Pupyshev AB; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Akopyan AA; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Tenditnik MV; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Ovsyukova MV; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Dubrovina NI; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Belichenko VM; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Korolenko TA; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
  • Zozulya SA; Mental Health Research Center, 115522 Moscow, Russia.
  • Klyushnik TP; Mental Health Research Center, 115522 Moscow, Russia.
  • Tikhonova MA; Laboratory of the Neurobiological Mechanisms of Neurodegenerative Processes, Department of Experimental Neuroscience, Scientific Research Institute of Neurosciences and Medicine (SRINM), 630017 Novosibirsk, Russia.
Pharmaceutics ; 16(6)2024 Jun 16.
Article en En | MEDLINE | ID: mdl-38931934
ABSTRACT
In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied the effects of different regimens of dietary trehalose treatment in an amyloid-ß (Aß) 25-35-induced murine model of Alzheimer's disease (AD). Aß-treated mice received 2% trehalose solution daily, 4% trehalose solution daily (continuous mode) or every other day (intermittent mode), to drink for two weeks. We revealed the dose-dependent effects on autophagy activation in the frontal cortex and hippocampus, and the restoration of behavioral disturbances. A continuous intake of 4% trehalose solution caused the greatest activation of autophagy and the complete recovery of step-through latency in the passive avoidance test that corresponds to associative long-term memory and learning. This regimen also produced an anxiolytic effect in the open field. The effects of all the regimens studied were similar in Aß load, neuroinflammatory response, and neuronal density in the frontal cortex and hippocampus. Trehalose successfully restored these parameters to the levels of the control group. Thus, high doses of trehalose had increased efficacy towards cognitive impairment in a model of early AD-like pathology. These findings could be taken into account for translational studies and the development of clinical approaches for AD therapy using trehalose.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza