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Metformin Therapy for Acne Vulgaris: A Meta-Analysis.
Szefler, Lidia; Szybiak-Skora, Weronika; Sadowska-Przytocka, Anna; Zaba, Ryszard; Wieckowska, Barbara; Lacka, Katarzyna.
Afiliación
  • Szefler L; Students' Scientific Society at Poznan University of Medical Sciences, Student's Scientific Section of Endocrinology, Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Szybiak-Skora W; Students' Scientific Society at Poznan University of Medical Sciences, Student's Scientific Section of Endocrinology, Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Sadowska-Przytocka A; Department of Allergic and Occupational Skin Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Zaba R; Department of Dermatology and Venerology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Wieckowska B; Department of Computer Sciences and Statistics, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Lacka K; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Science, 61-701 Poznan, Poland.
Pharmaceuticals (Basel) ; 17(6)2024 Jun 05.
Article en En | MEDLINE | ID: mdl-38931395
ABSTRACT
Acne vulgaris is a common disease, which occurs in adolescents as well as adults and has a significant influence on the patient's quality of life (QoL) in every aspect. Due to resistance to standard therapies, it has become necessary to prospect for new treatment strategies. It is important to highlight that the diagnosis and treatment of the underlying cause of acne such as metabolic and hormonal disorders may significantly improve the effectiveness of acne treatment. The correlation between Insulin Resistance (IR) and acne has been proven. Both disorders share many common occurrence factors and activation pathways. Metformin, an antihyperglycemic agent, seems to be a possible therapy option, not only because of its insulin sensitizing ability but also via plenty of additional effects of this medicine. While the efficiency of metformin therapy in patients with acne and Polycystic Ovary Syndrome (PCOS) is well explored, it is still necessary to evaluate it in patients without any endocrinopathies. This meta-analysis aimed to estimate the effectiveness of oral metformin as a monotherapy in acne patients without PCOS or other endocrinopathies. Study selection was performed with included criteria such as no PCOS and other endocrinopathies diagnosed, oral administration of metformin, and metformin in monotherapy. Selected studies contained comparisons in the Global Acne Grading System (GAGS) before and after metformin therapy. Statistical analysis detected significant improvement in skin condition after treatment with metformin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza