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Design and Characterization of a Novel Core-Shell Nano Delivery System Based on Zein and Carboxymethylated Short-Chain Amylose for Encapsulation of Curcumin.
Lin, Zhiwei; Zhan, Linjie; Qin, Kaili; Li, Yang; Qin, Yang; Yang, Lu; Sun, Qingjie; Ji, Na; Xie, Fengwei.
Afiliación
  • Lin Z; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
  • Zhan L; Qingdao Special Food Research Institute, Qingdao 266109, China.
  • Qin K; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
  • Li Y; Qingdao Special Food Research Institute, Qingdao 266109, China.
  • Qin Y; School of Public Health, Anhui University of Science and Technology, Huainan 232001, China.
  • Yang L; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
  • Sun Q; Qingdao Special Food Research Institute, Qingdao 266109, China.
  • Ji N; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
  • Xie F; Qingdao Special Food Research Institute, Qingdao 266109, China.
Foods ; 13(12)2024 Jun 11.
Article en En | MEDLINE | ID: mdl-38928779
ABSTRACT
Curcumin is a naturally occurring hydrophobic polyphenolic compound with a rapid metabolism, poor absorption, and low stability, which severely limits its bioavailability. Here, we employed a starch-protein-based nanoparticle approach to improve the curcumin bioavailability. This study focused on synthesizing nanoparticles with a zein "core" and a carboxymethylated short-chain amylose (CSA) "shell" through anti-solvent precipitation for delivering curcumin. The zein@CSA core-shell nanoparticles were extensively characterized for physicochemical properties, structural integrity, ionic stability, in vitro digestibility, and antioxidant activity. Fourier-transform infrared (FTIR) spectroscopy indicates nanoparticle formation through hydrogen-bonding, hydrophobic, and electrostatic interactions between zein and CSA. Zein@CSA core-shell nanoparticles exhibited enhanced stability in NaCl solution. At a zein-to-CSA ratio of 11.25, only 15.7% curcumin was released after 90 min of gastric digestion, and 66% was released in the intestine after 240 min, demonstrating a notable sustained release effect. Furthermore, these nanoparticles increased the scavenging capacity of the 1,1-diphenyl-2-picrylhydrazyl (DPPH•) free radical compared to those composed solely of zein and were essentially nontoxic to Caco-2 cells. This research offers valuable insights into curcumin encapsulation and delivery using zein@CSA core-shell nanoparticles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza