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Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Meta-Analysis of Randomized Controlled Trials and Trial Sequential Analysis.
Bhandari, Megha; Samanta, Jayanta; Spadaccini, Marco; Fugazza, Alessandro; Crinò, Stefano Francesco; Gkolfakis, Paraskevas; Triantafyllou, Konstantinos; Dhar, Jahnvi; Maida, Marcello; Pugliese, Nicola; Hassan, Cesare; Repici, Alessandro; Aghemo, Alessio; Serviddio, Gaetano; Facciorusso, Antonio.
Afiliación
  • Bhandari M; Hepatology Department, Cambridge University Hospital, Cambridge CB4 1GN, UK.
  • Samanta J; Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Spadaccini M; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Fugazza A; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Crinò SF; Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, 37134 Verona, Italy.
  • Gkolfakis P; Department of Gastroenterology, General Hospital of Nea Ionia "Konstantopoulio-Patision", 142 33 Athens, Greece.
  • Triantafyllou K; Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 124 62 Athens, Greece.
  • Dhar J; Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • Maida M; Faculty of Medicine, "Kore" University of Enna, 94100 Enna, Italy.
  • Pugliese N; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Hassan C; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Repici A; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Aghemo A; Endoscopy Unit, Department of Biomedical Sciences, Humanitas University, Humanitas Clinical and Research Center IRCCS, Rozzano, 20089 Milan, Italy.
  • Serviddio G; Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Via L Pinto 1, 71122 Foggia, Italy.
  • Facciorusso A; Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Via L Pinto 1, 71122 Foggia, Italy.
Diagnostics (Basel) ; 14(12)2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38928653
ABSTRACT

BACKGROUND:

The efficacy of endoscopic ultrasound-guided liver biopsy (EUS-LB) compared to percutaneous liver biopsy (PC-LB) remains uncertain.

METHODS:

Our data consist of randomized controlled trials (RCTs) comparing EUS-LB to PC-LB, found through a literature search via PubMed/Medline and Embase. The primary outcome was sample adequacy, whereas secondary outcomes were longest and total lengths of tissue specimens, diagnostic accuracy, and number of complete portal tracts (CPTs).

RESULTS:

Sample adequacy did not significantly differ between EUS-LB and PC-LB (risk ratio [RR] 1.18; 95% confidence interval [CI] 0.58-2.38; p = 0.65), with very low evidence quality and inadequate sample size as per trial sequential analysis (TSA). The two techniques were equivalent with respect to diagnostic accuracy (RR 1; CI 0.95-1.05; p = 0.88), mean number of complete portal tracts (mean difference 2.29, -4.08 to 8.66; p = 0.48), and total specimen length (mean difference -0.51, -20.92 to 19.9; p = 0.96). The mean maximum specimen length was significantly longer in the PC-LB group (mean difference -3.11, -5.51 to -0.71; p = 0.01), and TSA showed that the required information size was reached.

CONCLUSION:

EUS-LB and PC-LB are comparable in terms of diagnostic performance although PC-LB provides longer non-fragmented specimens.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza