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A Systematic Review of the Predictive and Diagnostic Uses of Neuroinflammation Biomarkers for Epileptogenesis.
Aguilar-Castillo, Maria Jose; Cabezudo-García, Pablo; García-Martín, Guillermina; Lopez-Moreno, Yolanda; Estivill-Torrús, Guillermo; Ciano-Petersen, Nicolas Lundahl; Oliver-Martos, Begoña; Narváez-Pelaez, Manuel; Serrano-Castro, Pedro Jesús.
Afiliación
  • Aguilar-Castillo MJ; Servicio de Análisis Clínicos, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Cabezudo-García P; Instituto de Investigación Biomédica de Málaga y Plataforma de Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
  • García-Martín G; Servicio de Neurología, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Lopez-Moreno Y; Alianza Andalucía Neuro-RECA-Roche en Neurología Médica de Precisión, 29010 Málaga, Spain.
  • Estivill-Torrús G; Instituto de Investigación Biomédica de Málaga y Plataforma de Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
  • Ciano-Petersen NL; Servicio de Neurología, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Oliver-Martos B; Alianza Andalucía Neuro-RECA-Roche en Neurología Médica de Precisión, 29010 Málaga, Spain.
  • Narváez-Pelaez M; Instituto de Investigación Biomédica de Málaga y Plataforma de Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
  • Serrano-Castro PJ; Servicio de Neurología, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Int J Mol Sci ; 25(12)2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38928193
ABSTRACT
A central role for neuroinflammation in epileptogenesis has recently been suggested by several investigations. This systematic review explores the role of inflammatory mediators in epileptogenesis, its association with seizure severity, and its correlation with drug-resistant epilepsy (DRE). The study analysed articles published in JCR journals from 2019 to 2024. The search strategy comprised the MESH, free terms of "Neuroinflammation", and selective searches for the following single biomarkers that had previously been selected from the relevant literature "High mobility group box 1/HMGB1", "Toll-Like-Receptor 4/TLR-4", "Interleukin-1/IL-1", "Interleukin-6/IL-6", "Transforming growth factor beta/TGF-ß", and "Tumour necrosis factor-alpha/TNF-α". These queries were all combined with the MESH terms "Epileptogenesis" and "Epilepsy". We found 243 articles related to epileptogenesis and neuroinflammation, with 356 articles from selective searches by biomarker type. After eliminating duplicates, 324 articles were evaluated, with 272 excluded and 55 evaluated by the authors. A total of 21 articles were included in the qualitative evaluation, including 18 case-control studies, 2 case series, and 1 prospective study. As conclusion, this systematic review provides acceptable support for five biomarkers, including TNF-α and some of its soluble receptors (sTNFr2), HMGB1, TLR-4, CCL2 and IL-33. Certain receptors, cytokines, and chemokines are examples of neuroinflammation-related biomarkers that may be crucial for the early diagnosis of refractory epilepsy or may be connected to the control of epileptic seizures. Their value will be better defined by future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteína HMGB1 / Enfermedades Neuroinflamatorias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteína HMGB1 / Enfermedades Neuroinflamatorias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza