Molecular Mechanisms Regulating Vascular Endothelial Permeability.

Wakasugi, Rio; Suzuki, Kenji; Kaneko-Kawano, Takako

Wakasugi, Rio; Suzuki, Kenji; Kaneko-Kawano, Takako.

Afiliación

Wakasugi R; Graduate School of Pharmacy, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.
Suzuki K; Graduate School of Pharmacy, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.
Kaneko-Kawano T; Graduate School of Pharmacy, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.

Int J Mol Sci ; 25(12)2024 Jun 11.

Article en En | MEDLINE | ID: mdl-38928121

ABSTRACT

ABSTRACT

Vascular endothelial cells form a monolayer in the vascular lumen and act as a selective barrier to control the permeability between blood and tissues. To maintain homeostasis, the endothelial barrier function must be strictly integrated. During acute inflammation, vascular permeability temporarily increases, allowing intravascular fluid, cells, and other components to permeate tissues. Moreover, it has been suggested that the dysregulation of endothelial cell permeability may cause several diseases, including edema, cancer, and atherosclerosis. Here, we reviewed the molecular mechanisms by which endothelial cells regulate the barrier function and physiological permeability.

Asunto(s)

Permeabilidad Capilar; Células Endoteliales; Endotelio Vascular; Humanos; Animales; Endotelio Vascular/metabolismo; Células Endoteliales/metabolismo; Transducción de Señal

Palabras clave

VE-cadherin; endothelial cell; permeability

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Endotelio Vascular / Células Endoteliales Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza

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