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Transcriptomic Analyses Reveal the Effects of Walnut Kernel Cake on Adipose Deposition in Pigs.
Liu, Lei; Shang, Xiaodan; Ma, Li; Yan, Dawei; Adetula, Adeyinka Abiola; Bai, Ying; Dong, Xinxing.
Afiliación
  • Liu L; College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
  • Shang X; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
  • Ma L; School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
  • Yan D; Department of Animal Husbandry and Veterinary Medicine, Yunnan Vocational and Technical College of Agriculture, Kunming 650212, China.
  • Adetula AA; College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
  • Bai Y; Reproductive Biotechnology, Department of Molecular Life Sciences, TUM School of Life Sciences, Technical University Munich, 85354 Freising, Germany.
  • Dong X; School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Genes (Basel) ; 15(6)2024 May 23.
Article en En | MEDLINE | ID: mdl-38927603
ABSTRACT
With the rising cost of animal feed protein, finding affordable and effective substitutes is crucial. Walnut kernel cake, a polyphenol-, fiber-, protein- and fat-rich byproduct of walnut oil extraction, has been underexplored as a potential protein replacement in pig feed. In this study, we found that feeding large Diqing Tibetan pigs walnut kernel cake promoted adipose deposition and improved pork quality during pig growth. Transcriptome analysis revealed the upregulation of genes ANGPTL8, CCNP, ETV4, and TRIB3, associated with adipose deposition. Pathway analysis highlighted enrichment in adipose deposition-related pathways, including PPAR, insulin, PI3K-Akt, Wnt, and MAPK signaling. Further analysis identified DEGs (differentially expressed genes) positively correlated with adipose-related traits, such as PER2 and PTGES. Single-cell transcriptome data pointed to the specific expression of CD248 and PTGES in adipocyte progenitor/stem cells (APSCs), pivotal for adipocyte differentiation and adipose deposition regulation. This study demonstrates walnut kernel cake's potential to substitute soybean cake in pig feed, providing high-quality protein and promoting adipose deposition. It offers insights into feed protein replacement, human functional food, fat metabolism, and related diseases, with marker genes and pathways supporting pig breeding and pork quality improvement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Juglans / Transcriptoma / Alimentación Animal Límite: Animals Idioma: En Revista: Genes (Basel) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Juglans / Transcriptoma / Alimentación Animal Límite: Animals Idioma: En Revista: Genes (Basel) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza