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The impact of telomere length on the risk of idiopathic normal pressure hydrocephalus: a bidirectional Mendelian randomization study.
Wang, Zhihao; Zuo, Mingrong; Li, Wenhao; Chen, Siliang; Yuan, Yunbo; He, Yuze; Yang, Yuan; Mao, Qing; Liu, Yanhui.
Afiliación
  • Wang Z; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Zuo M; Department of Pediatric Neurosurgery, West China Women's and Children's Hospital: Sichuan University West China Second University Hospital, Chengdu, 610041, China.
  • Li W; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Chen S; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Yuan Y; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • He Y; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Yang Y; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Mao Q; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
  • Liu Y; Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China. liuyh@scu.edu.cn.
Sci Rep ; 14(1): 14713, 2024 06 26.
Article en En | MEDLINE | ID: mdl-38926610
ABSTRACT
Idiopathic normal pressure hydrocephalus (iNPH) affects mainly aged populations. The gradual shortening of telomere length (TL) is one of the hallmarks of aging. Whereas the genetic contribution of TL to the iNPH is incompletely understood. We aimed to investigate the causal relationship between TL and iNPH through the Mendelian randomization (MR) analysis. We respectively obtained 186 qualified single nucleotide polymorphisms (SNPs) of TL and 20 eligible SNPs of iNPH for MR analysis. The result of MR analysis showed that genetically predicted longer TL was significantly associated with a reduced odd of iNPH (odds ratio [OR] = 0.634 95% Confidence interval [CI] 0.447-0.899, p = 0.011). The causal association remained consistent in multivariable MR (OR = 0.530 95% CI 0.327-0.860, p = 0.010). However, there was no evidence that the iNPH was causally associated with the TL (OR = 1.000 95% CI 0.996-1.004, p = 0.955). Our study reveals a potential genetic contribution of TL to the etiology of iNPH, that is a genetically predicted increased TL might be associated with a reduced risk of iNPH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Análisis de la Aleatorización Mendeliana / Hidrocéfalo Normotenso Límite: Aged / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Análisis de la Aleatorización Mendeliana / Hidrocéfalo Normotenso Límite: Aged / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido