Your browser doesn't support javascript.
loading
Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior.
Atlan, Gal; Matosevich, Noa; Peretz-Rivlin, Noa; Marsh-Yvgi, Idit; Zelinger, Noam; Chen, Eden; Kleinman, Timna; Bleistein, Noa; Sheinbach, Efrat; Groysman, Maya; Nir, Yuval; Citri, Ami.
Afiliación
  • Atlan G; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Matosevich N; Department of Physiology & Pharmacology, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Peretz-Rivlin N; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Marsh-Yvgi I; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Zelinger N; The Alexander Silberman Institute of Life Science, Faculty of Science, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Chen E; Department of Physiology & Pharmacology, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Kleinman T; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Bleistein N; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Sheinbach E; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Groysman M; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Nir Y; The Alexander Silberman Institute of Life Science, Faculty of Science, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
  • Citri A; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
Nat Commun ; 15(1): 5415, 2024 Jun 26.
Article en En | MEDLINE | ID: mdl-38926345
ABSTRACT
The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task ('ENGAGE'). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Claustro / Giro del Cíngulo / Neuronas Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Claustro / Giro del Cíngulo / Neuronas Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido