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Prevalence of crystal deposits in asymptomatic hyperuricemia according to different scanning definitions: A comparative study.
Peral-Garrido, María-Luisa; Gómez-Sabater, Silvia; Caño, Rocío; Bermúdez-García, Alejandra; Lozano, Teresa; Sánchez-Ortiga, Ruth; Perdiguero, Miguel; Caro-Martínez, Elena; Ruiz-García, Carolina; Francés, Rubén; Pascual, Eliseo; Andrés, Mariano.
Afiliación
  • Peral-Garrido ML; Vinalopó University Hospital, Elche, Spain; University Miguel Hernández de Elche (UMH), Alicante, Spain.
  • Gómez-Sabater S; University Miguel Hernández de Elche (UMH), Alicante, Spain; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain.
  • Caño R; University Miguel Hernández de Elche (UMH), Alicante, Spain; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain.
  • Bermúdez-García A; University Miguel Hernández de Elche (UMH), Alicante, Spain; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain.
  • Lozano T; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain; Cardiology Service, Dr. Balmis General University Hospital, Alicante, Spain.
  • Sánchez-Ortiga R; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain; Endocrinology and Nutrition Service, Dr. Balmis General University Hospital, Alicante, Spain.
  • Perdiguero M; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain; Nephrology Service, Dr. Balmis General University Hospital, Alicante, Spain.
  • Caro-Martínez E; Internal Medicine Service, Sant Vicent del Raspeig Hospital-HACLE, San Vicente del Raspeig, Spain.
  • Ruiz-García C; Campoamor Health Center, Alicante, Spain.
  • Francés R; University Miguel Hernández de Elche (UMH), Alicante, Spain; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain; Biomedical Research Network Center for Hepatic and Digestive Diseases (CIBEREHD), Spain.
  • Pascual E; University Miguel Hernández de Elche (UMH), Alicante, Spain; Alicante Healthcare and Biomedical Research Institute (ISABIAL), Alicante, Spain.
  • Andrés M; University Miguel Hernández de Elche (UMH), Alicante, Spain; Rheumatology Section, Dr. Balmis General University Hospital, Alicante, Spain; Alicante Healthcare and Biomedical Research Institute (ISABIAL), Alicante, Spain. Electronic address: mariano.andresc@umh.es.
Semin Arthritis Rheum ; 68: 152470, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38924926
ABSTRACT
BACKGROUND/

AIM:

The appropriate sonographic protocol for assessing urate crystal deposits in asymptomatic hyperuricemia (AH) is undefined, as well as how the choice would impact on deposit rates and accompanying sonographic, clinical and laboratory features.

METHODS:

Patients with AH (serum urate ≥7 mg/dL) underwent musculoskeletal ultrasound of 10 locations for OMERACT elementary gout lesions (double contour [DC] signs, tophi, aggregates). Different definitions for AH with deposits were applied, varying according to deposits (any deposits; only DC and/or tophi); gradation (any grade; only grade 2-3 deposits), location (10 locations; 4-joint scheme including knees and 1MTPs; >1 location with deposits), or pre-defined definitions (DC sign in femoral condyles/1MTP and/or tophi in 1MTP). We evaluated crystal deposits rates and compared between other sonographic features, clinical and laboratory variables.

RESULTS:

Seventy-seven participants with AH showed a median 1 location (IQR 0-2) with tophi, 1 (IQR 1-2) with aggregates, and 0 locations (IQR 0-1) with DC sign. The deposition rate ranged from 23.4% (in >1 location with grade 2-3 DC or tophi) to 87.0% (in any deposit in all 10 locations). Accompanying inflammation - assessed by a positive power-Doppler (PD) signal - and erosions were found in 19.5% and 28.4% of participants, respectively. Positive PD signal was better discriminated by criteria requiring grade 2-3 or >1 location with lesions. Erosions and the different clinical and laboratory variables were similar among protocols.

CONCLUSION:

Rates of sonographic deposition in AH varied dramatically among studied protocols, while some could discriminate accompanying inflammation, all highlighting the need for a validated, consensus-based definition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico / Ultrasonografía / Hiperuricemia / Gota Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Semin Arthritis Rheum Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico / Ultrasonografía / Hiperuricemia / Gota Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Semin Arthritis Rheum Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos