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Risk factors for progression from prediabetes to diabetes among older people with HIV.
Masters, Mary Clare; Tassiopoulos, Katherine; Bao, Yajing; Wu, Kunling; Koletar, Susan L; Rubin, Leah H; Yang, Jingyan; Overton, Edgar T; Letendre, Scott; Brown, Todd T; Erlandson, Kristine M; Palella, Frank J.
Afiliación
  • Masters MC; Northwestern University, Chicago, Illinois.
  • Tassiopoulos K; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Bao Y; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Wu K; Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Koletar SL; Ohio State University, Columbus, Ohio.
  • Rubin LH; Johns Hopkins University, Baltimore, Maryland.
  • Yang J; Columbia University, New York, New York.
  • Overton ET; University of Alabama at Birmingham and ViiV Healthcare, Birmingham, Alabama.
  • Letendre S; University of California, San Diego, San Diego, California.
  • Brown TT; Johns Hopkins University, Baltimore, Maryland.
  • Erlandson KM; University of Colorado, Aurora, Colorado, USA.
  • Palella FJ; Northwestern University, Chicago, Illinois.
AIDS ; 38(12): 1740-1748, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-38923420
ABSTRACT

OBJECTIVE:

Risk factors for progression from prediabetes mellitus (pre-DM) to diabetes mellitus (DM) among people with HIV (PWH) receiving modern antiretroviral therapy (ART) require better characterization.

DESIGN:

AIDS Clinical Trials Group (ACTG) A5322 (HAILO) was an observational cohort study of PWH ≥40 years old. Participants initiated ART through ACTG randomized clinical trials.

METHODS:

We used Cox proportional hazards regression models to identify risk factors for development of DM among HAILO participants with pre-DM.

RESULTS:

Among 1035 HAILO participants, 74 (7%) had pre-DM at entry and another 679 (66%) developed pre-DM during follow-up. Of 753 PWH with pre-DM, 167 (22%) developed DM. In multivariable models, the risk of developing DM was greater with higher BMI, lower CD4 count (≤200 cells/mm 3 ), hypertriglyceridemia, or higher waist circumference at pre-DM diagnosis ( P  < 0.01).

CONCLUSION:

Rates of pre-DM and progression to DM remain high among virally suppressed PWH receiving modern ART regimens. Traditional risks for DM, such as higher BMI or waist circumference, are associated with increased risk of incident DM among PWH with pre-DM. The association between lower CD4 + and progression to DM suggests a role for advanced immunodeficiency and inflammation. Further investigation of interventions aimed at preventing DM among PWH with pre-DM is needed. Optimizing prevention and treatment for DM may be an intervenable opportunity to improve long-term outcomes for PWH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Infecciones por VIH / Progresión de la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Infecciones por VIH / Progresión de la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido