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Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods.
McCullagh, J; Booth, C; Lancut, J; Platton, S; Richards, P; Green, L.
Afiliación
  • McCullagh J; Clinical Haematology, Barts Health NHS Trust, London, UK.
  • Booth C; NHS Blood and Transplant, London, UK.
  • Lancut J; Blizard Institute, Queen Mary University of London, London, UK.
  • Platton S; Clinical Haematology, Barts Health NHS Trust, London, UK.
  • Richards P; NHS Blood and Transplant, London, UK.
  • Green L; East and Southeast London Pathology Partnership, London, UK.
Transfus Med ; 34(4): 304-310, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38923078
ABSTRACT

BACKGROUND:

Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended pre-thawed plasma thus, reducing unnecessary plasma wastage. STUDY DESIGN AND

METHODS:

The aims of this study were to assess (a) the thawing times and (b) in vitro haemostatic quality of thawed plasma using Barkey Plasmatherm V (PTV) at 37 and 45°C versus Barkey Plasmatherm Classic (PTC) at 37 and 45°C, Sarstedt Sahara-III Maxitherm (SS-III) at 37°C and Helmer Scientific Thermogenesis Thermoline (TT) at 37°C. Haemostatic quality was assessed using LG-Octaplas at three different time points baseline (5 min), 24 and 120 h after thawing.

RESULTS:

The thawing time (SD) of 2 and 4 units was significantly different between different thawers. PTV at 45°C was the fastest method for both 2 and 4 units (7.06 min [0.68], 9.6 min [0.87], respectively). SS-III at 37°C being the slowest method (24.69 min [2.09] and 27.18 min [4.4], respectively) (p = < 0.05). Baseline measurements for all assays showed no significant difference in the prothrombin time, fibrinogen, FII, FV, protein C activity or free protein S antigen between all methods tested. However, at baseline PTV (both 37°C and 45°C) had significantly higher levels of FVII, FVIII and FXI and shortened activated partial thromboplastin time.

DISCUSSION:

PTV was the quickest method at thawing plasma at both 37 and at 45°C. The haemostatic quality of plasma thawed at 45 versus 37°C was not impaired. Thawing frozen plasma at 45°C should be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Criopreservación Límite: Female / Humans / Male Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Criopreservación Límite: Female / Humans / Male Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido