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The Use of Statins as an Adjunctive Periodontal Disease Treatment: Systematic Review and Meta-Analysis.
Greethurst, Alice Rose; Galletti, Cosimo; Lo Giudice, Roberto; Nart, José; Vallés, Cristina; Real-Voltas, Francisco; Gay-Escoda, Cosme; Marchetti, Enrico.
Afiliación
  • Greethurst AR; School of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
  • Galletti C; School of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
  • Lo Giudice R; Department of Human Pathology of Adults and Developmental Age, Messina University, 98100 Messina, Italy.
  • Nart J; Department of Periodontology, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
  • Vallés C; Department of Periodontology, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
  • Real-Voltas F; School of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
  • Gay-Escoda C; Oral and Maxillofacial Surgery Department, School of Dentistry, University of Barcelona, 08022 Barcelona, Spain.
  • Marchetti E; Department of Teknon Medical Center, IDIBELL Institute, 08022 Barcelona, Spain.
Dent J (Basel) ; 12(6)2024 May 21.
Article en En | MEDLINE | ID: mdl-38920851
ABSTRACT

BACKGROUND:

the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis.

METHODS:

Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included Randomized Controlled Trials (RCTs) published after 2010, where the periodontal variables were assessed before and after periodontal treatment in combination with a statin administration. The risk of bias was assessed with the ROBINS-2 tool. The outcome variables were probing depth, clinical attachment level, bleeding on probing, and bone fill in systematically healthy patients, patients with type 2 diabetes, and smokers.

RESULTS:

Out of 119 potentially eligible articles, 18 randomized controlled trials were included with a total of 1171 participants. The data retrieved from the meta-analysis showed the positive effect that statins have as an adjunctive periodontal disease treatment. When comparing the different types of statins, the PD reduction in the Simvastatin group was significantly higher than the Atorvastatin group at 6 months and at 9 months, while no differences between statins were found for the rest of the outcomes. Over 66% of the articles presented an overall risk of bias with some concerns, making this a limitation of this present RCT.

CONCLUSIONS:

The adjunct administration of statins has proven to have a positive effect on the periodontium by improving both clinical and radiographic parameters by a considerable margin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dent J (Basel) Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dent J (Basel) Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza