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Overcoming Barriers in Glioblastoma-Advances in Drug Delivery Strategies.
Ter Linden, Esther; Abels, Erik R; van Solinge, Thomas S; Neefjes, Jacques; Broekman, Marike L D.
Afiliación
  • Ter Linden E; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • Abels ER; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • van Solinge TS; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • Neefjes J; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • Broekman MLD; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Cells ; 13(12)2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38920629
ABSTRACT
The world of cancer treatment is evolving rapidly and has improved the prospects of many cancer patients. Yet, there are still many cancers where treatment prospects have not (or hardly) improved. Glioblastoma is the most common malignant primary brain tumor, and even though it is sensitive to many chemotherapeutics when tested under laboratory conditions, its clinical prospects are still very poor. The blood-brain barrier (BBB) is considered at least partly responsible for the high failure rate of many promising treatment strategies. We describe the workings of the BBB during healthy conditions and within the glioblastoma environment. How the BBB acts as a barrier for therapeutic options is described as well as various approaches developed and tested for passing or opening the BBB, with the ultimate aim to allow access to brain tumors and improve patient perspectives.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Barrera Hematoencefálica / Sistemas de Liberación de Medicamentos / Glioblastoma Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Barrera Hematoencefálica / Sistemas de Liberación de Medicamentos / Glioblastoma Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza