Collaborative action between noradrenergic and serotoninergic systems in peripheral antinociception in mice.

Aguiar, Danielle Diniz; Oliveira, Cristina DA Costa; Petrocchi, Julia Alvarenga; Castor, Marina Gomes Miranda E; Perez, Andrea Castro; Duarte, Igor Dimitri Gama; Romero, Thiago Roberto Lima

Aguiar, Danielle Diniz; Oliveira, Cristina DA Costa; Petrocchi, Julia Alvarenga; Castor, Marina Gomes Miranda E; Perez, Andrea Castro; Duarte, Igor Dimitri Gama; Romero, Thiago Roberto Lima.

Afiliación

Aguiar DD; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. AntoË nio Carlos, 31.270-100, Belo Horizonte 6627, Brazil.

J Biosci ; 492024.

Article en En | MEDLINE | ID: mdl-38920106

ABSTRACT

ABSTRACT

Noradrenaline (NA) and serotonin (5-HT) induce nociception and antinociception. This antagonistic effect can be explained by the dose and type of activated receptors. We investigated the existence of synergism between the noradrenergic and serotonergic systems during peripheral antinociception. The paw pressure test was performed in mice that had increased sensitivity by intraplantar injection of prostaglandin E2 (PGE2). Noradrenaline (80 ng) administered intraplantarly induced an antinociceptive effect, that was reversed by the administration of selective antagonists of serotoninergic receptors 5-HT1B isamoltan, 5-HT1D BRL15572, 5-HT2A ketanserin, 5-HT3 ondansetron, but not by selective receptor antagonist 5-HT7 SB-269970. The administration of escitalopram, a serotonin reuptake inhibitor, potentiated the antinociceptive effect at a submaximal dose of NA. These results, indicate the existence of synergism between the noradrenergic and serotonergic systems in peripheral antinociception in mice.

Asunto(s)

Norepinefrina; Receptores de Serotonina; Antagonistas de la Serotonina; Serotonina; Animales; Ratones; Norepinefrina/metabolismo; Serotonina/metabolismo; Antagonistas de la Serotonina/farmacología; Masculino; Receptores de Serotonina/metabolismo; Dinoprostona/metabolismo; Citalopram/farmacología; Nocicepción/efectos de los fármacos; Analgésicos/farmacología; Ondansetrón/farmacología; Ketanserina/farmacología; Dolor/tratamiento farmacológico; Dolor/metabolismo; Inhibidores Selectivos de la Recaptación de Serotonina/farmacología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Serotonina / Norepinefrina / Receptores de Serotonina Límite: Animals Idioma: En Revista: J Biosci Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: India

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