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Succinyl Curcumin Conjugated Chitosan Polymer-Prodrug Nanomicelles: A Potential Treatment for Type-II Diabetes in Diabetic Balb/C Mice.
Sk Mosiur, Rahaman; Dutta, Gouranga; Biswas, Ranu; Sugumaran, Abimanyu; M Salem, Mohamed; Gamal, Mohammed; AbdElrahman, Mohamed; M Salem-Bekhit, Mounir.
Afiliación
  • Sk Mosiur R; Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. mosiur@rediffmail.com.
  • Dutta G; Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur 603203, Tamilnadu, India. gourangadutta071994@gmail.com.
  • Biswas R; Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. rbiswas.pharmacy@jadavpuruniversity.in.
  • Sugumaran A; Department of Pharmaceutical Sciences, Assam University ( A Central University), Silchar, India. abipharmastar@gmail.com.
  • M Salem M; College of Medicine, Huazhong University of Science and Technology, China.. medozcockney@gmail.com.
  • Gamal M; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt.. mgamalm3000@yahoo.com.
  • AbdElrahman M; Clinical Pharmacy Department, College of Pharmacy, Al-Mustaqbal University, Babylon, 51001, Iraq. Mohamedmahmoud@mustaqbal-college.edu.iq.
  • M Salem-Bekhit M; Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. mbekhet@ksu.edu.sa.
Acta Chim Slov ; 71(2): 421-435, 2024 Jun 10.
Article en En | MEDLINE | ID: mdl-38919100
ABSTRACT
Diabetes mellitus is a chronic metabolic disorder marked by elevated blood sugar levels, leading to organ dysfunction. Curcumin, derived from turmeric, exhibits promise in managing type II diabetes. Nanomicelles were created by conjugating curcumin with chitosan through succinic anhydride. Succinyl-curcumin, the resultant compound, was esterified with chitosan to form a polymer prodrug conjugate. Nanomicelles, formed via dialysis, were spherical with a hydrodynamic size of 49.37 nm. In vitro release studies revealed 97% curcumin release at pH 5 in 7 days. A 21-day experiment on diabetic mice compared nanomicelles, standard drug, and free curcumin's impact on fasting blood glucose. The study showcased gradual, controlled curcumin release from nanomicelles, suggesting their potential in type II diabetes treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Curcumina / Quitosano / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Ratones Endogámicos BALB C / Micelas Límite: Animals Idioma: En Revista: Acta Chim Slov Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Eslovenia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Curcumina / Quitosano / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Ratones Endogámicos BALB C / Micelas Límite: Animals Idioma: En Revista: Acta Chim Slov Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Eslovenia