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Calcitonin-producing Duodenal Neuroendocrine Tumor: A Case Report and Literature Review.
Paz-Ibarra, José; Suárez-Rojas, Jacsel; Álvarez Gamero, Julio César; Concepción-Zavaleta, Marcio; Quiroz-Aldave, Juan Eduardo; Somocurcio-Peralta, José.
Afiliación
  • Paz-Ibarra J; Department of Medicine, School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Suárez-Rojas J; Division of Endocrinology, Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú.
  • Álvarez Gamero JC; Universidad Científica del Sur. Lima, Perú.
  • Concepción-Zavaleta M; Hospital Nacional Edgardo Rebagliati Martins Division of Endocrinology Lima Peru.
  • Quiroz-Aldave JE; Universidad Científica del Sur. Lima, Perú.
  • Somocurcio-Peralta J; Division of Non-communicable diseases, Endocrinology research line, Hospital de Apoyo Chepén. Chepén, Perú.
Endocr Metab Immune Disord Drug Targets ; 2024 Jun 24.
Article en En | MEDLINE | ID: mdl-38918999
ABSTRACT

INTRODUCTION:

Neuroendocrine tumors [NETs] exhibit a wide range of clinical presentations, including the production of various hormones. Calcitonin, a sensitive marker for medullary thyroid cancer [MTC], is nonspecific and may be elevated in extra-thyroidal NETs. CASE REPORT We present the case of a 64-year-old female patient who underwent total thyroidectomy due to a nodule in the isthmus, with a fine-needle aspiration biopsy indicating follicular neoplasia. Pathological examination revealed macro- and micro-nodular thyroid hyperplasia, along with a parathyroid adenoma. During postoperative follow-up, a progressive elevation of calcitonin was observed, reaching 64.2 pg/ml, while carcinoembryonic antigen levels remained normal. Since no MTC foci were found upon reviewing the thyroidectomy specimen, an investigation into the origin of the elevated calcitonin was initiated. Serum chromogranin A and specific neuronal enolase levels were within normal ranges. Tc-99m HYNIC-TOC scintigraphy yielded negative results. Additionally, an upper gastrointestinal endoscopy revealed a submucosal lesion in the second portion of the duodenum, with a biopsy confirming a grade 1 NET. The patient underwent Whipple surgery and hepatic metastasectomy. Postoperatively, a decrease in baseline serum calcitonin levels was observed. Seven years after surgery, she continues specialized monitoring with no biochemical or imaging evidence of disease.

CONCLUSION:

Serum calcitonin contributes to the diagnosis and monitoring of anterior intestine NETs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Asunto de la revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Asunto de la revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Emiratos Árabes Unidos