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GHS-R1a deficiency protects against lipopolysaccharide-induced spatial memory impairment in mice.
Liu, Junru; Li, Na; Wei, Chuang; Han, Fubing; Deng, Mingru; Ma, Jialin; Zou, Xueying; Zhou, Yu; Yang, Rong; Yuan, Haicheng.
Afiliación
  • Liu J; Department of Neurology, Affiliated Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group）Qingdao, Shandong 266042, China; Department of Neurology, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, China.
  • Li N; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China; Department of Medicine, Qingdao Binhai University, Qingdao, Shandong, 266555, China.
  • Wei C; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China.
  • Han F; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China; Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.
  • Deng M; Department of Neurology, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, China; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China.
  • Ma J; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China.
  • Zou X; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China.
  • Zhou Y; Department of Neurology, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, China; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong, 266071, China; Affiliated Qingdao Third People's Hospital, Department of Otorhinolaryn
  • Yang R; Affiliated Qingdao Third People's Hospital, Department of Otorhinolaryngology Head and Neck, Qingdao University, Qingdao, 266021, China. Electronic address: jhtyr@sina.com.
  • Yuan H; Department of Neurology, Affiliated Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group）Qingdao, Shandong 266042, China; Department of Neurology, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, China.
Biochem Biophys Res Commun ; 727: 150270, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-38917617
ABSTRACT
Neuroinflammation has been implicated in cognitive deficits of neurological and neurodegenerative diseases. There is abundant evidence that the application of ghrelin, an orexigenic hormone regulating appetite and energy balance, abrogates neuroinflammation and rescues associated memory impairment. However, the underlying mechanism is uncertain. In this study, we find that both intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of lipopolysaccharide (LPS) impairs spatial memory in mice. LPS treatment causes neuroinflammation and microglial activation in the hippocampus. Ghsr1a deletion suppresses LPS-induced microglial activation and neuroinflammation, and rescued LPS-induced memory impairment. Our findings thus suggest that GHS-R1a signaling may promote microglial immunoactivation and contribute to LPS-induced neuroinflammation. GHS-R1a may be a new therapeutic target for cognitive dysfunction associated with inflammatory conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Microglía / Receptores de Ghrelina / Memoria Espacial / Trastornos de la Memoria / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Microglía / Receptores de Ghrelina / Memoria Espacial / Trastornos de la Memoria / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos