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Differences in the consolidation by spontaneous and evoked ripples in the presence of active dendrites.
Jauch, Jannik; Becker, Moritz; Tetzlaff, Christian; Fauth, Michael Jan.
Afiliación
  • Jauch J; Third Institute for Physics, Georg-August-University, Göttingen, Germany.
  • Becker M; Group of Computational Synaptic Physiology, Department for Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.
  • Tetzlaff C; Group of Computational Synaptic Physiology, Department for Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.
  • Fauth MJ; Third Institute for Physics, Georg-August-University, Göttingen, Germany.
PLoS Comput Biol ; 20(6): e1012218, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38917228
ABSTRACT
Ripples are a typical form of neural activity in hippocampal neural networks associated with the replay of episodic memories during sleep as well as sleep-related plasticity and memory consolidation. The emergence of ripples has been observed both dependent as well as independent of input from other brain areas and often coincides with dendritic spikes. Yet, it is unclear how input-evoked and spontaneous ripples as well as dendritic excitability affect plasticity and consolidation. Here, we use mathematical modeling to compare these cases. We find that consolidation as well as the emergence of spontaneous ripples depends on a reliable propagation of activity in feed-forward structures which constitute memory representations. This propagation is facilitated by excitable dendrites, which entail that a few strong synapses are sufficient to trigger neuronal firing. In this situation, stimulation-evoked ripples lead to the potentiation of weak synapses within the feed-forward structure and, thus, to a consolidation of a more general sequence memory. However, spontaneous ripples that occur without stimulation, only consolidate a sparse backbone of the existing strong feed-forward structure. Based on this, we test a recently hypothesized scenario in which the excitability of dendrites is transiently enhanced after learning, and show that such a transient increase can strengthen, restructure and consolidate even weak hippocampal memories, which would be forgotten otherwise. Hence, a transient increase in dendritic excitability would indeed provide a mechanism for stabilizing memories.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dendritas / Consolidación de la Memoria / Hipocampo / Modelos Neurológicos / Plasticidad Neuronal Límite: Animals / Humans Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dendritas / Consolidación de la Memoria / Hipocampo / Modelos Neurológicos / Plasticidad Neuronal Límite: Animals / Humans Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos