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Combining Nontargeted Analysis with Computer-Based Hazard Comparison Approaches to Support Prioritization of Unregulated Organic Contaminants in Biosolids.
Newmeyer, Matthew N; Lyu, Qinfan; Sobus, Jon R; Williams, Antony J; Nachman, Keeve E; Prasse, Carsten.
Afiliación
  • Newmeyer MN; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland 21205, United States.
  • Lyu Q; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland 21205, United States.
  • Sobus JR; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27709, United States.
  • Williams AJ; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27709, United States.
  • Nachman KE; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland 21205, United States.
  • Prasse C; Risk Sciences and Public Policy Institute, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Environ Sci Technol ; 58(27): 12135-12146, 2024 Jul 09.
Article en En | MEDLINE | ID: mdl-38916220
ABSTRACT
Biosolids are a byproduct of wastewater treatment that can be beneficially applied to agricultural land as a fertilizer. While U.S. regulations limit metals and pathogens in biosolids intended for land applications, no organic contaminants are currently regulated. Novel techniques can aid in detection, evaluation, and prioritization of biosolid-associated organic contaminants (BOCs). For example, nontargeted analysis (NTA) can detect a broad range of chemicals, producing data sets representing thousands of measured analytes that can be combined with computational toxicological tools to support human and ecological hazard assessment and prioritization. We combined NTA with a computer-based tool from the U.S. EPA, the Cheminformatics Hazard Comparison Module (HCM), to identify and prioritize BOCs present in U.S. and Canadian biosolids (n = 16). Four-hundred fifty-one features were detected in at least 80% of samples, with identities of 92 compounds confirmed or assigned probable structures. These compounds were primarily categorized as endogenous compounds, pharmaceuticals, industrial chemicals, and fragrances. Examples of top prioritized compounds were p-cresol and chlorophene, based on human health end points, and fludioxonil and triclocarban, based on ecological health end points. Combining NTA results with hazard comparison data allowed us to prioritize compounds to be included in future studies of the environmental fate and transport of BOCs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aguas Residuales Límite: Humans Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aguas Residuales Límite: Humans Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos