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Vitamin D Levels in Patients with Noninfectious Uveitis: A Systematic Review and Meta-Analysis.
Cunha Amaral, Dillan; Takahashi, Rafael; Moraes, Henrique Maciel Vieira de; Rodrigues, Márcio Penha Morterá; Filho, Adroaldo de Alencar Costa; Moraes, Haroldo Vieira de; Noguera Louzada, Ricardo.
Afiliación
  • Cunha Amaral D; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Takahashi R; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Moraes HMV; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Rodrigues MPM; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Filho AAC; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Noguera Louzada R; Department of Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ocul Immunol Inflamm ; : 1-9, 2024 Jun 25.
Article en En | MEDLINE | ID: mdl-38916195
ABSTRACT

PURPOSE:

Vitamin D deficiency has been associated with higher rates of autoimmune disease, including noninfectious uveitis. This PRISMA-compliant review and meta-analysis aimed to analyze the correlation between noninfectious uveitis and vitamin D levels.

METHODS:

We searched PubMed, Embase, Cochrane, and Web of Science databases for studies, published in English, assessing vitamin D levels in patients diagnosed with noninfectious uveitis. The outcomes of interest were vitamin D deficiency, vitamin D mean level, vitamin D supplementation, and smoking rates. A subgroup analysis of inactive uveitis and active uveitis was performed. The heterogeneity was assessed with Cochrane Q-test and I2 statistics; p > 0.10 and I2 > 50% were considered significant for heterogeneity. Statistical analysis was conducted using Review Manager 5.3.

RESULTS:

9 studies were included in the meta-analysis comprising a total of 10 711 patients, of whom 1,368 were diagnosed with noninfectious uveitis. Patients with noninfectious uveitis had worse results regarding vitamin D deficiency when compared with the control group (OR 0.58; CI 95% 0.44 to 0.77; p = 0.0002; I2 = 61%). Patients with inactive uveitis had better results towards vitamin D deficiency when compared with active uveitis (OR 5.00; CI 95% 2.84 to 8.81; p < 0.001; I2 = 0%).

CONCLUSION:

Our research supports the increasing evidence that associates vitamin D deficiency with noninfectious uveitis and its activity. Further investigation into the efficacy of vitamin D screening and supplementation in reducing the recurrence of uveitis is necessary.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido