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Retention rate of abatacept in rheumatoid arthritis patients in a real-life setting: results from a monocentric cohort.
Molteni, E; Pirone, C; Ceccarelli, F; Castellani, C; Alessandri, C; Di Franco, M; Riccieri, V; Spinelli, F R; Priori, R; Scrivo, R; Conti, F.
Afiliación
  • Molteni E; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. emanuele.molteni@uniroma1.it.
  • Pirone C; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. pirone.carmelo@gmail.com.
  • Ceccarelli F; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. fulviaceccarelli@gmail.com.
  • Castellani C; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. chiara.castellani@uniroma1.it.
  • Alessandri C; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. cristiano.alessandri@uniroma1.it.
  • Di Franco M; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. manuela.difranco@uniroma1.it.
  • Riccieri V; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. valeria.riccieri@uniroma1.it.
  • Spinelli FR; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. francescaromana.spinelli@unrioma1.it.
  • Priori R; Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome; Saint Camillus International University of Health Science, UniCamillus, Rome. robertapriori63@gmail.com.
  • Scrivo R; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. rossana.scrivo@uniroma1.it.
  • Conti F; Rheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome. fabrizio.conti@uniroma1.it.
Reumatismo ; 76(2)2024 Jun 24.
Article en En | MEDLINE | ID: mdl-38916170
ABSTRACT

OBJECTIVE:

Data from trials demonstrated that abatacept (ABA) has a good safety and efficacy profile in treating rheumatoid arthritis. We have studied the retention rate of ABA in a real-life cohort of patients with rheumatoid arthritis.

METHODS:

This is a monocentric, retrospective study including patients with rheumatoid arthritis classified by the American College of Rheumatology/European League Against Rheumatism 2010 criteria who started treatment with ABA. The Kaplan-Meier method was applied to evaluate the ABA retention rate.

RESULTS:

This analysis was conducted on 161 patients [male/female 21/140, median age 65 years, interquartile range (IQR) 18.7, median disease duration 169 months, IQR 144.0]. 111 patients (68.9%) received ABA subcutaneously. ABA was associated with methotrexate in 61.9% of patients and was the first biological disease-modifying antirheumatic drug in 41%. We observed a median ABA survival of 66 months [95% confidence interval (CI) 57.3-74.7], with a retention rate of 88% at 6 months and 50.9% at 5 years. Drug survival was significantly higher in patients treated with ABA subcutaneously and in male patients (p=0.039 and p=0.018, respectively). Adjusted for main confounders, female gender was the main predictor of withdrawal (hazard ratio 5.1, 95% CI 1.2-21.3).

CONCLUSIONS:

Our study shows that better survival is associated with subcutaneous administration and male gender, confirming ABA effectiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Antirreumáticos / Abatacept Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Reumatismo Año: 2024 Tipo del documento: Article Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Antirreumáticos / Abatacept Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Reumatismo Año: 2024 Tipo del documento: Article Pais de publicación: Italia