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Cardiovascular Safety of COVID-19 Vaccination in Patients With Cancer: A Self-Controlled Case Series Study in Korea.
Ryu, Ji Hwa; Choi, Ahhyung; Woo, Jieun; Lee, Hyesung; Kim, Jinkwon; Yoo, Joonsang; Shin, Ju-Young.
Afiliación
  • Ryu JH; School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
  • Choi A; Department of Development, SK Bioscience, Seongnam, Korea.
  • Woo J; School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
  • Lee H; Harvard-MIT Center for Regulatory Science, Harvard Medical School, Boston, MA, USA.
  • Kim J; Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea.
  • Yoo J; School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
  • Shin JY; Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea.
J Korean Med Sci ; 39(24): e190, 2024 Jun 24.
Article en En | MEDLINE | ID: mdl-38915282
ABSTRACT

BACKGROUND:

Cancer patients have an increased risk of cardiovascular outcomes and are susceptible to coronavirus disease 2019 (COVID-19) infection. We aimed to assess the cardiovascular safety of COVID-19 vaccination for cancer patients in South Korea.

METHODS:

We conducted a self-controlled case series study using the K-COV-N cohort (2018-2021). Patients with cancer aged 12 years or older who experienced cardiovascular outcomes were identified. Cardiovascular outcomes were defined as myocardial infarction, stroke, venous thromboembolism (VTE), myocarditis, or pericarditis, and the risk period was 0-28 days after receiving each dose of COVID-19 vaccines. A conditional Poisson regression model was used to calculate the incidence rate ratio (IRR) with 95% confidence interval (CI).

RESULTS:

Among 318,105 patients with cancer, 4,754 patients with cardiovascular outcomes were included. The overall cardiovascular risk was not increased (adjusted IRR, 0.99 [95% CI, 0.90-1.08]) during the whole risk period. The adjusted IRRs of total cardiovascular outcomes during the whole risk period according to the vaccine type were 1.07 (95% CI, 0.95-1.21) in the mRNA vaccine subgroup, 0.99 (95% CI, 0.83-1.19) in the ChAdOx1 nCoV-19 vaccine subgroup, and 0.86 (95% CI, 0.68-1.10) in the mix-matched vaccination subgroup. However, in the analysis of individual outcome, the adjusted IRR of myocarditis was increased to 11.71 (95% CI, 5.88-23.35) during the whole risk period. In contrast, no increased risk was observed for other outcomes, such as myocardial infarction, stroke, VTE, and pericarditis.

CONCLUSION:

For cancer patients, COVID-19 vaccination demonstrated an overall safe profile in terms of cardiovascular outcomes. However, caution is required as an increased risk of myocarditis following COVID-19 vaccination was observed in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Neoplasias Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Neoplasias Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur