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The link between Alzheimer's disease and stroke: A detrimental synergism.
Behl, Tapan; Kaur, Ishnoor; Sehgal, Aayush; Khandige, Prasanna Shama; Imran, Mohd; Gulati, Monica; Khalid Anwer, Md; Elossaily, Gehan M; Ali, Nemat; Wal, Pranay; Gasmi, Amin.
Afiliación
  • Behl T; Amity School of Pharmaceutical Sciences, Amity University, Mohali, Punjab, India. Electronic address: tapanbehl31@gmail.com.
  • Kaur I; University of Glasgow, College of Medical, Veterinary and Life Sciences, Glasgow, United Kingdom.
  • Sehgal A; GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India.
  • Khandige PS; NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Department of Pharmacology, Mangaluru, Karnataka, India.
  • Imran M; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
  • Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 1444411, India; ARCCIM, Faculty of Health, University of Technology Sydney, Ultimo, NSW 20227, Australia.
  • Khalid Anwer M; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
  • Elossaily GM; Department of Baisc Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.
  • Ali N; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Wal P; PSIT Kanpur, Department of Pharmacy, Uttar Pradesh, India.
  • Gasmi A; Societe Francophone de Nutritherapie et de Nutrigenetique Appliquee, Villeurbanne, France; International Institute of Nutrition and Micronutrition Sciences, Saint Etienne, France.
Ageing Res Rev ; 99: 102388, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38914265
ABSTRACT
Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients. Accumulation of amyloid-ß plaques and neurofibrillary tangled impair cognitive potential, leading to AD. Blocked blood flow in the neuronal tissues, causes neurodegeneration and cell death in stroke. AD is commonly characterized by cerebral amyloid angiopathy, which significantly elevates the risk of hemorrhagic stroke. Patients with AD and stroke have been both reported to exhibit greater cognitive impairment, followed by multiple pathophysiological mechanisms shared between the two. The manuscript aims to elucidate the relationship between AD and stroke, as well as the common pathways and risk factors while understanding the preventive therapies that might limit the negative impacts of this correlation, with diagnostic modalities and current AD treatments. The authors provide a comprehensive review of the link and aid the healthcare professionals to identify suitable targets and risk factors, that may retard cognitive decline and neurodegeneration in patients. However, more intricate research is required in this regard and an interdisciplinary approach that would target both the vascular and neurodegenerative factors would improve the quality of life in AD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido