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Estimated bone mineral density and white matter hyperintensities: A bidirectional Mendelian randomization study.
Li, Xiaoling; Wu, Xiaoju; Zhou, Guoqiu; Mo, Dongcan; Lin, Xiaozuo; Wang, Pingkai; Zeng, Yinan; Luo, Man.
Afiliación
  • Li X; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, China.
  • Wu X; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Zhou G; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Mo D; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Lin X; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, China.
  • Wang P; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, China.
  • Zeng Y; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Luo M; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, China; Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanni
Bone ; 187: 117138, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38914213
ABSTRACT

PURPOSE:

Greater white matter hyperintensities (WMH) in older adults have been associated with reduced bone mineral density (BMD) and increased fractures and falls. However, it is unclear whether there is a causal relationship between BMD reduction and WMH. In this study, Mendelian randomization (MR) was used to find the causality between WMH and estimated BMD (eBMD).

METHODS:

We performed a two-sample bidirectional MR analysis using statistical data obtained from publicly available genome-wide association studies (GWAS). The main method of MR analysis is the inverse-variance weighted (IVW) method. To identify and account for the impact of horizontal pleiotropy, we also employed MR-Egger regression, MR pleiotropy residual sum, and outlier (MR-PRESSO).

RESULTS:

MR analysis found a causal relationship between eBMD and WMH (IVW OR = 0.938, 95 % CI 0.889-0.990, p = 0.020). Our causal estimates are unlikely to be distorted by horizontal pleiotropy according to heterogeneity test (both p > 0.05) and MR-Egger regression (p > 0.05). However, in the reverse MR analysis, there was no evidence that WMH was causally correlated with eBMD (IVW OR = 0.979, 95 % CI 0.954-1.005, p = 0.109).

CONCLUSION:

Our results suggest that low eBMD increased the risk of WMH; conversely, no evidence that WMH causally affects eBMD was found.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Sustancia Blanca Límite: Humans Idioma: En Revista: Bone Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Sustancia Blanca Límite: Humans Idioma: En Revista: Bone Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos