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Catechol compounds as dual-targeting agents for fish protection against Ichthyophthirius multifiliis infections.
Qu, Shen-Ye; Liu, Yi-Hang; Liu, Jie-Tao; Li, Peng-Fei; Liu, Tian-Qiang; Wang, Gao-Xue; Yu, Qing; Ling, Fei.
Afiliación
  • Qu SY; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Liu YH; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Liu JT; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Li PF; Guangxi Academy of Sciences, Nanning, 530000, China.
  • Liu TQ; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Wang GX; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Yu Q; Guangxi Academy of Sciences, Nanning, 530000, China. Electronic address: yu_qing1990@163.com.
  • Ling F; Northwest A&F University, Xinong Road, Yangling, Shaanxi, 712100, China; Engineering Research Center of the Innovation and Development of Green Fishery Drugs, Universities of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: feiling@nwsuaf.edu.
Fish Shellfish Immunol ; 151: 109717, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38914179
ABSTRACT
Aquaculture is one of the fastest growing sectors in global food production, recognized as a significant contributor to poverty alleviation, food security, and income generation. However, the frequent occurrence of diseases caused by pathogen infections result in reduced yields and economic losses, posing a substantial constraint to the sustainable development of aquaculture. Here, our study identified that four catechol compounds, quercetin, luteolin, caffeic acid, and chlorogenic acid, exhibited potent antiparasitic effects against Ichthyophthirius multifiliis in both, in vitro and in vivo. The parasite is recognized as one of the most pathogenic to fish worldwide. Using a combination of in silico methods, the dipeptidyl peptidase (DPP) was identified as a critical target for catechol compounds. The two hydroxyl radicals of the catechol group were essential for its binding to and interacting with the DPP protein. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated that catechol compounds disrupt pathways associated with the metabolism and growth of I. multifiliis, thereby exerting antiparasitic effects. Furthermore, these compounds attenuated the expression of proinflammatory cytokines in vivo in fish and promoted macrophage polarization toward M2 phenotype by inhibiting the STAT1 signaling pathway. The dual activity of catechol compounds, acting as both direct antiparasitic and anti-inflammatory agents in fish, offers a promising therapeutic approach for combating I. multifiliis infections in aquaculture.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / Hymenostomatida / Infecciones por Cilióforos / Enfermedades de los Peces Límite: Animals Idioma: En Revista: Fish Shellfish Immunol Asunto de la revista: BIOLOGIA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / Hymenostomatida / Infecciones por Cilióforos / Enfermedades de los Peces Límite: Animals Idioma: En Revista: Fish Shellfish Immunol Asunto de la revista: BIOLOGIA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido