Nanorobot-Based Direct Implantation of Flexible Neural Electrode for BCI.
IEEE Trans Biomed Eng
; 71(10): 3014-3023, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-38913534
ABSTRACT
Brain-Computer Interface (BCI) has gained remarkable prominence in biomedical community. While BCI holds vast potential across diverse domains, the implantation of neural electrodes poses multifaceted challenges to fully explore the power of BCI. Conventional rigid electrodes face the problem of foreign body reaction induced by mechanical mismatch to biological tissue, while flexible electrodes, though more preferential, lack controllability during implantation. Researchers have explored various strategies, from assistive shuttle to biodegradable coatings, to strike a balance between implantation rigidity and post-implantation flexibility. Yet, these approaches may introduce complications, including immune response, inflammations, and raising intracranial pressure. To this end, this paper proposes a novel nanorobot-based technique for direct implantation of flexible neural electrodes, leveraging the high controllability and repeatability of robotics to enhance the implantation quality. This approach features a dual-arm nanorobotic system equipped with stereo microscope, by which a flexible electrode is first visually aligned to the target neural tissue to establish contact and thereafter implanted into brain with well controlled insertion direction and depth. The key innovation is, through dual-arm coordination, the flexible electrode maintains straight along the implantation direction. With this approach, we implanted CNTf electrodes into cerebral cortex of mouse, and captured standard spiking neural signals.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Robótica
/
Electrodos Implantados
/
Interfaces Cerebro-Computador
Límite:
Animals
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos