Your browser doesn't support javascript.
loading
Docetaxel versus androgen receptor signaling inhibitor (ARSI) against chemo-naïve castration-resistant prostate cancer (CRPC): propensity score matched analysis in real world.
Shimomura, Tatsuya; Mori, Keiichiro; Ito, Kagenori; Yasue, Keiji; Matsukawa, Akihiro; Fukuokaya, Wataru; Yanagisawa, Takafumi; Hata, Kenichi; Murakami, Masaya; Koike, Yusuke; Miki, Jun; Yamada, Hiroki; Kimura, Takahiro.
Afiliación
  • Shimomura T; Department of Urology, Jikei University School of Medicine, Tokyo, Japan. shimomura@jikei.ac.jp.
  • Mori K; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Ito K; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Yasue K; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Matsukawa A; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Fukuokaya W; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Yanagisawa T; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Hata K; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Murakami M; Department of Urology, Atsugi City General Hospital, Atsugi, Japan.
  • Koike Y; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Miki J; Department of Urology, Fuji City General Hospital, Fuji, Japan.
  • Yamada H; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
  • Kimura T; Department of Urology, JR Tokyo General Hospital, Tokyo, Japan.
Int Urol Nephrol ; 2024 Jun 24.
Article en En | MEDLINE | ID: mdl-38913290
ABSTRACT

PURPOSE:

Although docetaxel and ARSI are picked up as treatment options against chemo-naïve metastatic CRPC in clinical guidelines for prostate cancer, there is no clear evidence which agent should be introduced as first line treatment. Therefore, we investigated our CRPC cohort treated with docetaxel or ARSI as first-line agent against chemo-naïve CRPC to solve these clinical questions. PATIENTS AND

METHODS:

A total of 345 chemotherapy-naïve CRPC patients introduced to first-line docetaxel or ARSI (abiraterone or enzalutamide) between March 2006 and April 2017 at Jikei University Hospital and its affiliated institutions were included in this study. Propensity score matching method was used to minimize the patients' background. The outcome measures were PSA response rate, PSA decline ≥ 90%, cancer specific survival (CSS) and overall survival (OS).

RESULTS:

PSA decline correlated OS and CSS (p = 0.027, < 0.001, respectively) and median PSA decline rate was 60.4% in docetaxel group and 85.7% in ARSI group (p = 0.0311). Median OS was 33 m (95%CI 27-53) in docetaxel group and 61 m (95%CI 47-NA) in ARSI group (p = 0.0246). Median CSS was 34 m (95%CI 27-53) in docetaxel group and NR (not reached) (95%CI 61-NA) in ARSI group (p = 0.000133) in propensity score matching cohort. In multivariate analysis, ARSI induction first showed significantly better for OS and CSS (p = 0.0033 and < 0.001, respectively).

CONCLUSION:

In this study, better survival outcome with ARSI induction first than docetaxel against chemo-naïve CRPC. And the candidates who had survival benefit by induction docetaxel first could not be found in this study.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos