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Historic obstacles and emerging opportunities in the field of developmental metabolism - lessons from Heidelberg.
Garfinkel, Alexandra M; Ilker, Efe; Miyazawa, Hidenobu; Schmeisser, Kathrin; Tennessen, Jason M.
Afiliación
  • Garfinkel AM; Pediatric Genomics Discovery Program, Department of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Ilker E; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06510, USA.
  • Miyazawa H; Max Planck Institute for the Physics of Complex Systems, Dresden 01187, Germany.
  • Schmeisser K; Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
  • Tennessen JM; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
Development ; 151(12)2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38912552
ABSTRACT
The field of developmental metabolism is experiencing a technological revolution that is opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors, single-cell RNA sequencing and computational modeling present new opportunities for exploring cell-specific and tissue-specific metabolic networks, interorgan metabolic communication, and gene-by-metabolite interactions in time and space. Together, these advances not only present a means by which developmental biologists can tackle questions that have challenged the field for centuries, but also present young scientists with opportunities to define new areas of inquiry. These emerging frontiers of developmental metabolism were at the center of a highly interactive 2023 EMBO workshop 'Developmental metabolism flows of energy, matter, and information'. Here, we summarize key discussions from this forum, emphasizing modern developmental biology's challenges and opportunities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología Evolutiva Límite: Animals / Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología Evolutiva Límite: Animals / Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido