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Alteration of hyperpolarization-activated cation current-mediated metaplasticity contributes to electroconvulsive shock-induced learning and memory impairment in depressed rats.
Ren, Li; Yu, Jian; Chen, Hengsheng; Luo, Jie; Lv, Feng; Min, Su.
Afiliación
  • Ren L; Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Yu J; Department of Psychiatry, Shanghai 10th People's Hospital, Anesthesia and Brain Research Institute, Tongji University, Shanghai, China.
  • Chen H; Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
  • Luo J; Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Lv F; Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Min S; Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Psychiatry ; 15: 1365119, 2024.
Article en En | MEDLINE | ID: mdl-38911706
ABSTRACT

Background:

Accompanied by a rapid and effective antidepressant effect, electroconvulsive shock (ECS) can also induce learning and memory impairment. Our previous research reported that metaplasticity is involved in this process. However, the mechanisms still remain unclear. This study investigated the role of I h current in the metaplastic changes and learning and memory impairment induced by ECS in depressive rats.

Methods:

Depressive rats received ECS after modelling using chronic unpredictable. ZD7288, a type of I h current inhibitor was used to verify the effect of I h current. The sucrose preference test and Morris water maze were used for behavior testing. Changes in metaplasticity was assessed with the LTD/LTP threshold by stimulation at different frequencies. Spontaneous and evoked action potentials (APs) were measured to confirm difference of neuronal excitability. Additionally, the amplitude of I h current was analyzed.

Results:

ECS exerts antidepressant effect, but also induce spatial learning and memory dysfunction. ECS up-regulates the LTD/LTP threshold. In rats treated with ECS, the frequency of spontaneous and evoked APs is significantly reduced. In addition, ECS induces changes in the intrinsic properties of AP, including a decrease of AP-half width and peak amplitude, and an increase in AP time to peak and post-hyperpolarization potential amplitude. In particular, ECS increases both instantaneous and steady-state I h currents. However, Inhibition of I h current with ZD7288 results in a relief of learning and memory impairment and a decrease in threshold, as well as a significant reversal of whole-cell electrophysiological changes.

Conclusion:

ECS-induced learning and memory impairment is caused by neuronal hypoexcitability mediated metaplasticity, and upregulation of LTD/LTP threshold by an increase in I h current.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza