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A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer's Disease in a Real-World Setting.
Jang, Hyemin; Na, Duk L; Kwon, Jay Cheol; Jung, Na-Yeon; Moon, Yeonsil; Lee, Jung Seok; Park, Kyung-Won; Lee, Ae Young; Cho, Hanna; Lee, Jae-Hong; Kim, Byeong C; Park, Kee Hyung; Lee, Byung-Chul; Choi, Hojin; Kim, Jieun; Park, Mee Young.
Afiliación
  • Jang H; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Na DL; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Kwon JC; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Jung NY; Department of Neurology, Changwon Fatima Hospital, Changwon, Republic of Korea.
  • Moon Y; Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Lee JS; Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
  • Park KW; Department of Neurology, Jeju National University College of Medicine, Jeju, Republic of Korea.
  • Lee AY; Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, Republic of Korea.
  • Cho H; Department of Neurology, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
  • Lee JH; Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim BC; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Park KH; Department of Neurology, Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea.
  • Lee BC; Department of Neurology, College of Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
  • Choi H; Department of Neurology, College of Medicine, Hallym University, Seoul, Republic of Korea.
  • Kim J; Department of Neurology, Hanyang University Guri Hospital, Guri, Republic of Korea.
  • Park MY; Department of Medical, Eisai Korea Inc., Seoul, Republic of Korea.
J Alzheimers Dis Rep ; 8(1): 851-862, 2024.
Article en En | MEDLINE | ID: mdl-38910942
ABSTRACT

Background:

Predicting conversion to probable Alzheimer&s disease (AD) from amnestic mild cognitive impairment (aMCI) is difficult but important. A nomogram was developed previously for determining the risk of 3-year probable AD conversion in aMCI.

Objective:

To compare the probable AD conversion rates with cognitive and neurodegenerative changes for 2 years from high- and low risk aMCI groups classified using the nomogram.

Methods:

This prospective, multicenter, observational study was conducted in Korea. A total of patients were classified as high- or low-risk aMCI according to the nomogram and followed-up for 2 years to compare the annual conversion rate to probable AD and brain structure changes between the two groups.

Results:

In total, 176 (high-risk, 85; low-risk, 91) and 160 (high-risk, 77; low-risk, 83) patients completed the 1-year and 2-year follow-up, respectively. The probable AD conversion rate was significantly higher in the high-risk (Year 1, 28.9%; Year 2, 46.1%) versus low-risk group (Year 1, 0.0%; Year 2, 4.9%, both p < 0.0001). Mean changes from baseline in Seoul Neuropsychological Screening Battery-Dementia Version, Clinical Dementia Rating-Sum of Box, and Korean version of the Instrumental Activities of Daily Living scores and cortical atrophy index at Years 1 and 2 were significantly greater in the high-risk group (p < 0.0001).

Conclusions:

The high-risk aMCI group, as determined by the nomogram, had a higher conversion rate to probable AD and faster cognitive decline and neurodegeneration change than the low-risk group. These real-world results have clinical implications that help clinicians in accurately predicting patient outcomes and facilitating early decision-making.Trial Registration ClinicalTrials.gov (NCT03448445).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos