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Ionic Liquid-Based Silane for SiO2 Nanoparticles: A Versatile Coupling Agent for Dental Resins.
Garcia, Isadora Martini; Souza, Virgínia Serra de; Balhaddad, Abdulrahman A; Mokeem, Lamia; Melo, Mary Anne Sampaio de; Scholten, Jackson Damiani; Collares, Fabrício Mezzomo.
Afiliación
  • Garcia IM; Division of Cariology and Operative Dentistry, Department of Comprehensive Dentistry, University of Maryland School of Dentistry, Baltimore, Maryland 21201, United States.
  • Souza VS; Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil.
  • Balhaddad AA; Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Avenue, 9500, Agronomia, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
  • Mokeem L; Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
  • Melo MAS; Dental Biomedical Sciences Ph.D. Program, University of Maryland School of Dentistry, Baltimore, Maryland 21201, United States.
  • Scholten JD; Division of Cariology and Operative Dentistry, Department of Comprehensive Dentistry, University of Maryland School of Dentistry, Baltimore, Maryland 21201, United States.
  • Collares FM; Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Avenue, 9500, Agronomia, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
ACS Appl Mater Interfaces ; 16(26): 34057-34068, 2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38910292
ABSTRACT
The current longevity of dental resins intraorally is limited by susceptibility to acidic attacks from bacterial metabolic byproducts and vulnerability to enzymatic or hydrolytic degradation. Here, we demonstrate synthesizing an ionic liquid-based antibiofilm silane effective against Streptococcus mutans, a major caries pathogen. Furthermore, we incorporate this silane into dental resins, creating antibiofilm- and degradation-resistant materials applicable across resin types. FTIR, UV-vis, and NMR spectroscopy confirmed the synthesis of the expected ionic liquid-based silane. The characterization of SiO2 after the silanization indicated the presence of the silane and how it interacted with the oxide. All groups achieved a degree of conversion similar to that found for commercial resin composites immediately and after two months of storage in water. The minimum of 2.5 wt % of silane led to lower softening in solvent than the control group (GCTRL) (p < 0.05). While the flexural strength indicated a lower value from 1 wt % of silane compared to GCTRL (p < 0.05), the ultimate tensile strength did not indicate differences among groups (p > 0.05). There was no difference within groups between the immediate and long-term tests of flexural strength (p > 0.05) or ultimate tensile strength (p > 0.05). The addition of at least 5 wt % of silane reduced the viability of S. mutans compared to GCTRL (p < 0.05). The fluorescence microscopy analysis suggested that the higher the silane concentration, the higher the amount of bacteria with membrane defects. There was no difference among groups in the cytotoxicity test (p > 0.05). Therefore, the developed dental resins displayed biocompatibility, proper degree of conversion, improved resistance against softening in solvent, and stability after 6 months of storage in water. This material could be further developed to produce polymeric antimicrobial layers for different surfaces, supporting various potential avenues in developing novel biomaterials with enhanced therapeutic characteristics using ionic liquid-based materials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silanos / Streptococcus mutans / Dióxido de Silicio / Líquidos Iónicos / Nanopartículas Límite: Animals Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silanos / Streptococcus mutans / Dióxido de Silicio / Líquidos Iónicos / Nanopartículas Límite: Animals Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos