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Efficacy of anti-VEGF intravitreal injection in traumatic submacular hemorrhage: a retrospective study.
Wang, Jiaming; Huang, Liuhui; Chen, Lifei; Chen, Sheng; Liu, Shenwen.
Afiliación
  • Wang J; Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, 18th Zetian Road, Futian District, Shenzhen, 518040, China.
  • Huang L; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, 3002, Australia.
  • Chen L; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, 3010, Australia.
  • Chen S; Department of Ophthalmology, Tenth People's Hospital Affiliated with Shanghai Tongji University School of Medicine, Shanghai, 200072, China.
  • Liu S; Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, 18th Zetian Road, Futian District, Shenzhen, 518040, China.
Int Ophthalmol ; 44(1): 259, 2024 Jun 23.
Article en En | MEDLINE | ID: mdl-38909337
ABSTRACT

OBJECTIVE:

In this study we investigated the efficacy of short-term intravitreal injections of anti-vascular endothelial growth factors (anti-VEGF) in treating traumatic submacular hemorrhage.

METHODS:

A total of 115 patients were diagnosed with submacular hemorrhage between 2018 and 2022 at Shenzhen Eye Hospital. In a retrospective analysis, we examined 13 of these patients who presented with submacular hemorrhage and choroidal rupture due to ocular trauma. Eight patients were treated with intravitreal anti-VEGF injection and 5 with oral drugs. We systematically analyzed changes in their ocular conditions pre and post-treatment. The evaluations encompassed best-corrected visual acuity (BCVA), optical coherence tomography, fundus fluorescein angiography, and retinal imaging.

RESULTS:

The 13 patients diagnosed with submacular hemorrhage comprised of 10 males and 3 female, with their age ranging between 27 and 64 years, with an average age of 38.1 years (standard deviation [SD] 11.27). A statistically significant reduction in central foveal thickness (CFT) was observed following intravitreal injections of anti-VEGF drugs (P = 0.03). In control group, the CFT was reduced without statistical significance (P = 0.10). The BCVA of the patients in treatment group improved significantly from 1.15 (SD 0.62. Range 0.4-2) to 0.63 (SD 0.59. Range 0.1-1.6), indicating an average increase of 4.13 lines (SD 3.36. Range 0-9) as measured by the visual acuity test using an eye chart (P = 0.01). The difference between baseline visual acuity and final visual acuity was not statistically significant in control group (P = 0.51).

CONCLUSION:

Short-term administration of anti-VEGF drugs exhibited significant efficacy in reducing submacular hemorrhage following ocular trauma and enhancing visual acuity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Retiniana / Angiografía con Fluoresceína / Agudeza Visual / Lesiones Oculares / Inhibidores de la Angiogénesis / Factor A de Crecimiento Endotelial Vascular / Tomografía de Coherencia Óptica / Inyecciones Intravítreas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Retiniana / Angiografía con Fluoresceína / Agudeza Visual / Lesiones Oculares / Inhibidores de la Angiogénesis / Factor A de Crecimiento Endotelial Vascular / Tomografía de Coherencia Óptica / Inyecciones Intravítreas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos