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CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
Sun, Jinpeng; Shi, Mohan; Song, Zeyuan; Hua, Feng; Yan, Xiyun; Zhang, Mingshun; Duan, Hongxia; Liu, Jun.
Afiliación
  • Sun J; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Shi M; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Song Z; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Hua F; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Yan X; Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Nanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan 451163, China.
  • Zhang M; NHC Key Laboratory of Antibody Technique, Jiangsu Province Engineering Research Center of Antibody Drug, Department of Immunology, Nanjing Medical University, Nanjing, China. Electronic address: mingshunzhang@njmu.edu.cn.
  • Duan H; Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: cherryshoen@aliyun.com.
  • Liu J; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: 13776698080@139.com.
Int Immunopharmacol ; 137: 112528, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-38908086
ABSTRACT
Low back pain due to epidural fibrosis is a major complication after spine surgery. Macrophages infiltrate the wound area post laminectomy, but the role of macrophages in epidural fibrosis remains largely elusive. In a mouse model of laminectomy, macrophage depletion decreased epidural fibrosis. CD146, an adhesion molecule involved in cell migration, is expressed by macrophages. CD146-defective macrophages exhibited impaired migration, which was mediated by reduced expression of CCR2 and suppression of the MAPK/ERK signaling pathway. CD146-defective macrophages suppress the MAPK/ERK signaling pathway by increasing Erdr1. In vivo, CD146 deficiency decreased macrophage infiltration and reduced extracellular matrix deposition in wound tissues. Moreover, the anti-CD146 antibody AA98 suppressed macrophage infiltration and epidural fibrosis. Taken together, these findings demonstrated that CD146 deficiency alleviates epidural fibrosis by decreasing the migration of macrophages via the Erdr1/ERK/CCR2 pathway. Blocking CD146 and macrophage infiltration may help alleviate epidural fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis / Antígeno CD146 / Receptores CCR2 / Macrófagos / Ratones Endogámicos C57BL Límite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis / Antígeno CD146 / Receptores CCR2 / Macrófagos / Ratones Endogámicos C57BL Límite: Animals / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos