Biclustering for Epi-Transcriptomic Co-functional Analysis.

Chen, Shutao; Zhang, Lin; Liu, Hui

Chen, Shutao; Zhang, Lin; Liu, Hui.

Afiliación

Chen S; School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China.
Zhang L; School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China. lin.zhang@cumt.edu.cn.
Liu H; School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China. hui.liu@cumt.edu.cn.

Methods Mol Biol ; 2822: 293-309, 2024.

Article en En | MEDLINE | ID: mdl-38907925

ABSTRACT

ABSTRACT

Dynamic and reversible N6-methyladenosine (m6A) modifications are associated with many essential cellular functions as well as physiological and pathological phenomena. In-depth study of m6A co-functional patterns in epi-transcriptomic data may help to understand its complex regulatory mechanisms. In this chapter, we describe several biclustering mining algorithms for epi-transcriptomic data to discover potential co-functional patterns. The concepts and computational methods discussed in this chapter will be particularly useful for researchers working in related fields. We also aim to introduce new deep learning techniques into the field of co-functional analysis of epi-transcriptomic data.

Asunto(s)

Adenosina; Algoritmos; Biología Computacional; Transcriptoma; Adenosina/análogos & derivados; Adenosina/metabolismo; Biología Computacional/métodos; Humanos; Análisis por Conglomerados; Perfilación de la Expresión Génica/métodos; Aprendizaje Profundo; Epigénesis Genética; Epigenómica/métodos; Programas Informáticos

Palabras clave

Biclustering method; Co-functional analysis; Epi-transcriptomic data; m6A methylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algoritmos / Adenosina / Biología Computacional / Transcriptoma Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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