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A multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome.
Huang, Liansha; Guo, Ruochun; Li, Shenghui; Wu, Xiaoling; Zhang, Yue; Guo, Shumin; Lv, Ying; Xiao, Zhen; Kang, Jian; Meng, Jinxin; Zhou, Peng; Ma, Jie; You, Wei; Zhang, Yan; Yu, Hailong; Zhao, Jixin; Huang, Guangrong; Duan, Zuzhen; Yan, Qiulong; Sun, Wen.
Afiliación
  • Huang L; Department of Reproductive Health, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Guo R; Puensum Genetech Institute, Wuhan, China.
  • Li S; Puensum Genetech Institute, Wuhan, China. lsh2@qq.com.
  • Wu X; Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. lsh2@qq.com.
  • Zhang Y; Department of Reproductive Health, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Guo S; Puensum Genetech Institute, Wuhan, China.
  • Lv Y; Department of Reproductive Health, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Xiao Z; Department of Reproductive Health, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Kang J; Department of Obstetrics and Gynecology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Meng J; Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
  • Zhou P; Puensum Genetech Institute, Wuhan, China.
  • Ma J; Department of Acupuncture, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • You W; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Zhang Y; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
  • Yu H; Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Zhao J; Puensum Genetech Institute, Wuhan, China.
  • Huang G; Puensum Genetech Institute, Wuhan, China.
  • Duan Z; Department of Gynecology, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Yan Q; Department of Gynecology, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Sun W; Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. qiulongy1988@163.com.
Nat Microbiol ; 9(8): 2185-2200, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38907008
ABSTRACT
The human vagina harbours diverse microorganisms-bacteria, viruses and fungi-with profound implications for women's health. Genome-level analysis of the vaginal microbiome across multiple kingdoms remains limited. Here we utilize metagenomic sequencing data and fungal cultivation to establish the Vaginal Microbial Genome Collection (VMGC), comprising 33,804 microbial genomes spanning 786 prokaryotic species, 11 fungal species and 4,263 viral operational taxonomic units. Notably, over 25% of prokaryotic species and 85% of viral operational taxonomic units remain uncultured. This collection significantly enriches genomic diversity, especially for prevalent vaginal pathogens such as BVAB1 (an uncultured bacterial vaginosis-associated bacterium) and Amygdalobacter spp. (BVAB2 and related species). Leveraging VMGC, we characterize functional traits of prokaryotes, notably Saccharofermentanales (an underexplored yet prevalent order), along with prokaryotic and eukaryotic viruses, offering insights into their niche adaptation and potential roles in the vagina. VMGC serves as a valuable resource for studying vaginal microbiota and its impact on vaginal health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Vagina / Microbiota Límite: Female / Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Vagina / Microbiota Límite: Female / Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido