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Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study.
Maes, Lauranne; Vervenne, Thibault; Hendrickx, Amber; Estrada, Ana C; Van Hoof, Lucas; Verbrugghe, Peter; Rega, Filip; Jones, Elizabeth A V; Humphrey, Jay D; Famaey, Nele.
Afiliación
  • Maes L; BioMechanics, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium. Electronic address: lauranne.maes@kuleuven.be.
  • Vervenne T; BioMechanics, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
  • Hendrickx A; Cardiac Surgery, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Estrada AC; Department of Biomedical Engineering, Yale University, New Haven CT, USA.
  • Van Hoof L; Cardiac Surgery, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Verbrugghe P; Cardiac Surgery, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Rega F; Cardiac Surgery, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Jones EAV; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; CARIM School for Cardiovascular Diseases, Department of Cardiology, Maastricht University, Maastricht, Netherlands.
  • Humphrey JD; Department of Biomedical Engineering, Yale University, New Haven CT, USA.
  • Famaey N; BioMechanics, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
J Biomech ; 171: 112180, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38906711
ABSTRACT
In the Ross procedure, a patient's pulmonary valve is transplanted in the aortic position. Despite advantages of this surgery, reoperation is still needed in many cases due to excessive dilatation of the pulmonary autograft. To further understand the failure mechanisms, we propose a multiscale model predicting adaptive processes in the autograft at the cell and tissue scale. The cell-scale model consists of a network model, that includes important signaling pathways and relations between relevant transcription factors and their target genes. The resulting gene activity leads to changes in the mechanical properties of the tissue, modeled as a constrained mixture of collagen, elastin and smooth muscle. The multiscale model is calibrated with findings from experiments in which seven sheep underwent the Ross procedure. The model is then validated against a different set of sheep experiments, for which a qualitative agreement between model and experiment is found. Model outcomes at the cell scale, including the activity of genes and transcription factors, also match experimentally obtained transcriptomics data.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Pulmonar Límite: Animals / Humans Idioma: En Revista: J Biomech Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Pulmonar Límite: Animals / Humans Idioma: En Revista: J Biomech Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos