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Exploring the local field potential signal from the subthalamic nucleus for phase-targeted auditory stimulation in Parkinson's disease.
Krugliakova, Elena; Karpovich, Artyom; Stieglitz, Lennart; Huwiler, Stephanie; Lustenberger, Caroline; Imbach, Lukas; Bujan, Bartosz; Jedrysiak, Piotr; Jacomet, Maria; Baumann, Christian R; Fattinger, Sara.
Afiliación
  • Krugliakova E; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Karpovich A; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Stieglitz L; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Huwiler S; Neural Control of Movement Lab, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
  • Lustenberger C; Neural Control of Movement Lab, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
  • Imbach L; Swiss Epilepsy Center, Clinic Lengg, Zurich, Switzerland.
  • Bujan B; Neurorehabilitation, Clinic Lengg, Zurich, Switzerland.
  • Jedrysiak P; Neurorehabilitation, Clinic Lengg, Zurich, Switzerland.
  • Jacomet M; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Baumann CR; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Fattinger S; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address: sara.fattinger@kispi.uzh.ch.
Brain Stimul ; 17(4): 769-779, 2024.
Article en En | MEDLINE | ID: mdl-38906529
ABSTRACT

BACKGROUND:

Enhancing slow waves, the electrophysiological (EEG) manifestation of non-rapid eye movement (NREM) sleep, could potentially benefit patients with Parkinson's disease (PD) by improving sleep quality and slowing disease progression. Phase-targeted auditory stimulation (PTAS) is an approach to enhance slow waves, which are detected in real-time in the surface EEG signal.

OBJECTIVE:

We aimed to test whether the local-field potential of the subthalamic nucleus (STN-LFP) can be used to detect frontal slow waves and assess the electrophysiological changes related to PTAS.

METHODS:

We recruited patients diagnosed with PD and undergoing Percept™ PC neurostimulator (Medtronic) implantation for deep brain stimulation of STN (STN-DBS) in a two-step surgery. Patients underwent three full-night recordings, including one between-surgeries recording and two during rehabilitation, one with DBS+ (on) and one with DBS- (off). Surface EEG and STN-LFP signals from Percept PC were recorded simultaneously, and PTAS was applied during sleep in all three recording sessions.

RESULTS:

Our results show that during NREM sleep, slow waves of the cortex and STN are time-locked. PTAS application resulted in power and coherence changes, which can be detected in STN-LFP.

CONCLUSION:

Our findings suggest the feasibility of implementing PTAS using solely STN-LFP signal for slow wave detection, thus without a need for an external EEG device alongside the implanted neurostimulator. Moreover, we propose options for more efficient STN-LFP signal preprocessing, including different referencing and filtering to enhance the reliability of cortical slow wave detection in STN-LFP recordings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Estimulación Acústica / Núcleo Subtalámico / Estimulación Encefálica Profunda / Electroencefalografía Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Stimul Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Estimulación Acústica / Núcleo Subtalámico / Estimulación Encefálica Profunda / Electroencefalografía Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Stimul Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos