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Chronic Tonsillitis and IgA Nephropathy: Findings From a Nationwide Japanese Cohort Study.
Nakayama, Takashin; Kaneko, Hidehiro; Suzuki, Yuta; Okada, Akira; Morita, Hiroyuki; Fujiu, Katsuhito; Takeda, Norifumi; Fukui, Akira; Yokoo, Takashi; Takeda, Norihiko; Yasunaga, Hideo; Nangaku, Masaomi; Hayashi, Kaori.
Afiliación
  • Nakayama T; Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
  • Kaneko H; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan; Department of Advanced Cardiology, The University of Tokyo, Tokyo, Japan. Electronic address: kanekohidehiro@gmail.com.
  • Suzuki Y; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan; Center for Outcomes Research and Economic Evaluation for Health, National Institute of Public Health, Saitama, Japan.
  • Okada A; Department of Prevention of Diabetes and Lifestyle-Related Diseases, The University of Tokyo, Tokyo, Japan.
  • Morita H; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
  • Fujiu K; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan; Department of Advanced Cardiology, The University of Tokyo, Tokyo, Japan.
  • Takeda N; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
  • Fukui A; Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Jikei University, Tokyo, Japan.
  • Yokoo T; Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Jikei University, Tokyo, Japan.
  • Takeda N; Graduate School of Medicine, and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
  • Yasunaga H; Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
  • Nangaku M; Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
  • Hayashi K; Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Am J Kidney Dis ; 84(5): 613-620.e1, 2024 Nov.
Article en En | MEDLINE | ID: mdl-38906505
ABSTRACT
RATIONALE &

OBJECTIVE:

Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. STUDY

DESIGN:

Observational cohort study. SETTING &

PARTICIPANTS:

4,311,393 individuals without a history of IgAN identified between January 2005 and May 2022 within a Japanese nationwide epidemiological database, the JMDC Claims Database, representing health claims to over 60 insurers. EXPOSURE Comorbid chronic tonsillitis based on diagnosis codes.

OUTCOME:

IgAN occurrence. ANALYTICAL

APPROACH:

Cause-specific Cox proportional hazards analysis adjusting for potential confounding factors was employed to estimate hazard ratios (HRs).

RESULTS:

Comorbid chronic tonsillitis was identified in 12,842 individuals, constituting 0.3% of the cohort. The cohort had a median age of 44 years (IQR, 36-53), and males accounted for 57.9%, with a follow-up of 1,089 days (IQR, 532-1,797), during which 2,653 cases of IgAN developed. Cumulative incidence curve showed a higher cumulative incidence of IgAN in individuals with chronic tonsillitis compared with their counterparts without this condition. Multivariable cause-specific analysis further demonstrated that individuals with chronic tonsillitis had an elevated risk of developing IgAN, with HR of 2.72 (95% CI, 1.79-4.14).

LIMITATIONS:

Potential residual confounders, and lack of consideration for ethnic distinctions.

CONCLUSIONS:

Using a large-scale epidemiological dataset, these findings suggest a relationship between chronic tonsillitis and an elevated risk of IgAN development in the general Japanese population. PLAIN-LANGUAGE

SUMMARY:

IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis worldwide, is associated with unfavorable long-term kidney survival and life expectancy. Despite the substantial implications, the early detection of IgAN still remains challenging due to its commonly asymptomatic clinical presentation. Consequently, the exploration of risk factors assumes a critical research priority. Prior studies have reported the potential role of tonsilitis in the pathogenesis of IgAN. In this study, we assessed whether chronic tonsillitis was associated with the subsequent development of IgAN using a nationwide epidemiological dataset incorporating over 4,000,000 individuals. Within this large-scale cohort, our findings revealed an association between a history of tonsillitis and a greater risk of developing IgAN. These findings should heighten awareness of the potential susceptibility of people with chronic tonsilitis to IgAN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tonsilitis / Glomerulonefritis por IGA Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Am J Kidney Dis Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tonsilitis / Glomerulonefritis por IGA Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Am J Kidney Dis Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos