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A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice.
Hesser, Lauren A; Puente, Armando A; Arnold, Jack; Ionescu, Edward; Mirmira, Anjali; Talasani, Nidhi; Lopez, Jacqueline; Maccio-Maretto, Lisa; Mimee, Mark; Nagler, Cathryn R.
Afiliación
  • Hesser LA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.
  • Puente AA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.
  • Arnold J; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.
  • Ionescu E; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA.
  • Mirmira A; Department of Pathology, The University of Chicago, Chicago, IL, USA.
  • Talasani N; Department of Pathology, The University of Chicago, Chicago, IL, USA.
  • Lopez J; Department of Pathology, The University of Chicago, Chicago, IL, USA.
  • Maccio-Maretto L; Department of Pathology, The University of Chicago, Chicago, IL, USA.
  • Mimee M; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA; Committee on Microbiology, The University of Chicago, Chicago, IL, USA.
  • Nagler CR; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA; Department of Pathology, The University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA. Electronic address: cnagler1@uchicago.edu.
Cell Host Microbe ; 32(7): 1163-1176.e6, 2024 Jul 10.
Article en En | MEDLINE | ID: mdl-38906158
ABSTRACT
Depletion of beneficial microbes by modern lifestyle factors correlates with the rising prevalence of food allergies. Re-introduction of allergy-protective bacteria may be an effective treatment strategy. We characterized the fecal microbiota of healthy and food-allergic infants and found that the anaerobe Anaerostipes caccae (A. caccae) was representative of the protective capacity of the healthy microbiota. We isolated a strain of A. caccae from the feces of a healthy infant and identified lactulose as a prebiotic to optimize butyrate production by A. caccae in vitro. Administration of a synbiotic composed of our isolated A. caccae strain and lactulose increased luminal butyrate in gnotobiotic mice colonized with feces from an allergic infant and in antibiotic-treated specific pathogen-free (SPF) mice, and prevented or treated an anaphylactic response to allergen challenge. The synbiotic's efficacy in two models and microbial contexts suggests that it may be a promising approach for the treatment of food allergy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heces / Simbióticos / Microbioma Gastrointestinal / Hipersensibilidad a los Alimentos / Lactulosa Límite: Animals / Female / Humans / Infant / Male Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heces / Simbióticos / Microbioma Gastrointestinal / Hipersensibilidad a los Alimentos / Lactulosa Límite: Animals / Female / Humans / Infant / Male Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos