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Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction.
Langston, Harry; Fortes Francisco, Amanda; Doidge, Ciaran; Roberts, Chrissy H; Khan, Archie A; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M; Lewis, Michael D.
Afiliación
  • Langston H; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Fortes Francisco A; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Doidge C; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Roberts CH; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Khan AA; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Jayawardhana S; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Taylor MC; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Kelly JM; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Lewis MD; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
PLoS Negl Trop Dis ; 18(6): e0012278, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38905323
ABSTRACT
Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi. Clinical outcomes range from long-term asymptomatic carriage to cardiac, digestive, neurological and composite presentations that can be fatal in both acute and chronic stages of the disease. Studies of T. cruzi in animal models, principally mice, have informed our understanding of the biological basis of this variability and its relationship to infection and host response dynamics. Hamsters have higher translational value for many human infectious diseases, but they have not been well developed as models of Chagas disease. We transposed a real-time bioluminescence imaging system for T. cruzi infection from mice into female Syrian hamsters (Mesocricetus auratus). This enabled us to study chronic tissue pathology in the context of spatiotemporal infection dynamics. Acute infections were widely disseminated, whereas chronic infections were almost entirely restricted to the skin and subcutaneous adipose tissue. Neither cardiac nor digestive tract disease were reproducible features of the model. Skeletal muscle had only sporadic parasitism in the chronic phase, but nevertheless displayed significant inflammation and fibrosis, features also seen in mouse models. Whereas mice had normal locomotion, all chronically infected hamsters developed hindlimb muscle hypertonia and a gait dysfunction resembling spastic diplegia. With further development, this model may therefore prove valuable in studies of peripheral nervous system involvement in Chagas disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Mesocricetus / Enfermedad de Chagas / Modelos Animales de Enfermedad Límite: Animals Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Mesocricetus / Enfermedad de Chagas / Modelos Animales de Enfermedad Límite: Animals Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos