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Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine ß-globin polymorphism.
Okino, Cintia Hiromi; Niciura, Simone Cristina Méo; Minho, Alessandro Pelegrine; Esteves, Sérgio Novita; Melito, Gláucia Roberta; Montassier, Hélio José; Chagas, Ana Carolina de Souza.
Afiliación
  • Okino CH; Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234 s/n, Fazenda Canchim, PO Box 339, 13560-970, São Carlos, SP, Brazil. Electronic address: cintia.okino@embrapa.br.
  • Niciura SCM; Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234 s/n, Fazenda Canchim, PO Box 339, 13560-970, São Carlos, SP, Brazil.
  • Minho AP; Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234 s/n, Fazenda Canchim, PO Box 339, 13560-970, São Carlos, SP, Brazil.
  • Esteves SN; Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234 s/n, Fazenda Canchim, PO Box 339, 13560-970, São Carlos, SP, Brazil.
  • Melito GR; Centro Universitário Central Paulista (UNICEP), R. Miguel Petroni, 5111, 13563-470, São Carlos, SP, Brazil.
  • Montassier HJ; Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP), Via de Acesso Prof. Paulo Donato Castellane, s/n, 14884-900, Jaboticabal, São Paulo, Brazil.
  • Chagas ACS; Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234 s/n, Fazenda Canchim, PO Box 339, 13560-970, São Carlos, SP, Brazil.
Dev Comp Immunol ; 159: 105216, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38901502
ABSTRACT
Lambs harboring the Hb-AA ß-globin haplotype present improved cell-mediated responses and increased resistance against Haemonchus contortus infection. The aim of the present study was to compare the effect of sex and ß-globin haplotypes on specific humoral responses and phenotypes of resistance during H. contortus infection in Morada Nova sheep. As expected, females displayed stronger resistance during the first and second experimental challenges. Differential systemic humoral immune responses were observed comparing sex groups, in which higher levels of specific antibodies targeting 24 kDa excretory-secretory (ES24) protein of H. contortus of IgG and IgM antibodies were respectively observed as predominant isotypes in males and females. The IgM levels were significantly correlated with phenotypes of resistance, evaluated by packed cell volume and fecal egg counts. To our knowledge this is the first study reporting divergent humoral responses profiles to H. contortus infection between male and female sheep. The impact of ß-globin haplotypes was less pronounced in females compared to males. Notably, only males showed significant weight differences across haplotypes, with Hb-AA lambs being the heaviest. Additionally, Hb-AA males had significantly higher PCV (indicating better red blood cell health) and lower FEC (indicating lower parasite burden). These findings suggest a more pronounced effect of ß-globin polymorphisms on H. contortus infection in males, potentially due to their generally weaker resistance compared to females. This study highlights the importance of sex and ß-globin haplotypes in shaping immune responses to H. contortus infection. Specifically, IgM antibodies targeting the ES24 protein appear to play a crucial role in host-parasite interactions and may hold promise for therapeutic development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Enfermedades de las Ovejas / Globinas beta / Inmunidad Humoral / Hemoncosis / Haemonchus Límite: Animals Idioma: En Revista: Dev Comp Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Enfermedades de las Ovejas / Globinas beta / Inmunidad Humoral / Hemoncosis / Haemonchus Límite: Animals Idioma: En Revista: Dev Comp Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos