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Clinical comprehensive treatment protocol for managing diabetic foot ulcers: A retrospective cohort study.
Wang, Yan-Bin; Lv, Yan; Li, Guang-Yu; Zheng, Ji-Ting; Jiang, Qing-Xin; Wei, Ran.
Afiliación
  • Wang YB; Department of Vascular Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China. wyb1376010705@163.com.
  • Lv Y; First Department of General Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China.
  • Li GY; Department of Vascular Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China.
  • Zheng JT; Department of Vascular Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China.
  • Jiang QX; First Department of General Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China.
  • Wei R; First Department of General Surgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China.
World J Clin Cases ; 12(17): 2976-2982, 2024 Jun 16.
Article en En | MEDLINE | ID: mdl-38898850
ABSTRACT

BACKGROUND:

Diabetic foot ulcers (DFUs) are a common complication of diabetes, often leading to severe infections, amputations, and reduced quality of life. The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications. A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs. The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing, reduced amputation rates, and improved overall patient outcomes compared to standard treatment protocols.

AIM:

To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.

METHODS:

This retrospective study included 62 patients with DFUs, enrolled between January 2022 and January 2024, randomly assigned to the experimental (n = 32) or control (n = 30) group. The experimental group received a comprehensive treatment comprising blood circulation improvement, debridement, vacuum sealing drainage, recombinant human epidermal growth factor and anti-inflammatory dressing, and skin grafting. The control group received standard treatment, which included wound cleaning and dressing, antibiotics administration, and surgical debridement or amputation, if necessary. Time taken to reduce the white blood cell count, number of dressing changes, wound healing rate and time, and amputation rate were assessed.

RESULTS:

The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate, wound healing time, and amputation rate. Additionally, the comprehensive treatment protocol was safe and well tolerated by the patients.

CONCLUSION:

Comprehensive treatment for DFUs is more effective than standard treatment, promoting granulation tissue growth, shortening hospitalization time, reducing pain and amputation rate, improving wound healing, and enhancing quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Clin Cases Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Clin Cases Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos