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Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies.
Nayab, Saira; Jan, Kalsoom; Kim, Seung-Hyeon; Kim, Sa-Hyun; Shams, Dilawar Farhan; Son, Younghu; Yoon, Minyoung; Lee, Hyosun.
Afiliación
  • Nayab S; Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal Dir (U) 18050, Khyber Pakhtunkhwa, Islamic Republic of Pakistan.
  • Jan K; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea. myyoon@knu.ac.kr.
  • Kim SH; Department of Plastics Engineering, University of Massachusetts Lowell, Lowell, MA 01851, USA.
  • Kim SH; Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01851, USA.
  • Shams DF; BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
  • Son Y; BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
  • Yoon M; Department of Environmental Chemistry, Abdul Wali Khan University Maradan, Khyber Pakhtunkhwa, Islamic Republic of Pakistan.
  • Lee H; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea. myyoon@knu.ac.kr.
Dalton Trans ; 53(27): 11295-11309, 2024 Jul 09.
Article en En | MEDLINE | ID: mdl-38898716
ABSTRACT
A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(II) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(II) center. In vitro investigation of the synthesized ligand and its M(II) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 µM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bases de Schiff / Tiofenos / Ureasa / Complejos de Coordinación / Simulación del Acoplamiento Molecular / Antineoplásicos Límite: Humans Idioma: En Revista: Dalton Trans Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bases de Schiff / Tiofenos / Ureasa / Complejos de Coordinación / Simulación del Acoplamiento Molecular / Antineoplásicos Límite: Humans Idioma: En Revista: Dalton Trans Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido