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The Citrus flavanone naringenin prolongs the lifespan in C. elegans and slows signs of brain aging in mice.
Piragine, Eugenia; De Felice, Martina; Germelli, Lorenzo; Brinkmann, Vanessa; Flori, Lorenzo; Martini, Claudia; Calderone, Vincenzo; Ventura, Natascia; Da Pozzo, Eleonora; Testai, Lara.
Afiliación
  • Piragine E; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center "Nutrafood-Nutraceuticals and Food for Health", University of Pisa, Italy. Electronic address: eugenia.piragine@unipi.it.
  • De Felice M; Department of Pharmacy, University of Pisa, Italy. Electronic address: martina.defelice@phd.unipi.it.
  • Germelli L; Department of Pharmacy, University of Pisa, Italy. Electronic address: lorenzo.germelli@farm.unipi.it.
  • Brinkmann V; Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany. Electronic address: brinkmann.van@gmail.com.
  • Flori L; Department of Pharmacy, University of Pisa, Italy. Electronic address: lorenzo.flori@farm.unipi.it.
  • Martini C; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center "Nutrafood-Nutraceuticals and Food for Health", University of Pisa, Italy. Electronic address: claudia.martini@unipi.it.
  • Calderone V; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center "Biology and Pathology of Ageing", University of Pisa, Italy; Interdepartmental Research Center "Nutrafood-Nutraceuticals and Food for Health", University of Pisa, Italy. Electronic address: vincenzo.calderone@unipi
  • Ventura N; Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany. Electronic address: natascia.ventura@uni-duesseldorf.de.
  • Da Pozzo E; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center "Nutrafood-Nutraceuticals and Food for Health", University of Pisa, Italy. Electronic address: eleonora.dapozzo@unipi.it.
  • Testai L; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center "Biology and Pathology of Ageing", University of Pisa, Italy; Interdepartmental Research Center "Nutrafood-Nutraceuticals and Food for Health", University of Pisa, Italy. Electronic address: lara.testai@unipi.it.
Exp Gerontol ; 194: 112495, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38897393
ABSTRACT
Aging is one of the main risk factors for neurodegenerative disorders, which represent a global burden on healthcare systems. Therefore, identifying new strategies to slow the progression of brain aging is a compelling challenge. In this article, we first assessed the potential anti-aging effects of the Citrus flavanone naringenin (NAR), an activator of the enzyme sirtuin-1 (SIRT1), in a 3R-compliant and short-lived aging model (i.e., the nematode C. elegans). Then, we investigated the preventive effects of a 6-month treatment with NAR (100 mg/kg, orally) against brain aging and studied its mechanism of action in middle-aged mice. We demonstrated that NAR (100 µM) extends lifespan and improves healthspan in C. elegans. In the brain of middle-aged mice, NAR promotes the activity of metabolic enzymes (citrate synthase, cytochrome C oxidase) and increases the expression of the SIRT1 enzyme. Consistently, NAR up-regulates the expression of downstream antioxidant (Foxo3, Nrf2, Ho-1), anti-senescence (p16), and anti-inflammatory (Il-6, Il-18) markers. Our findings support NAR supplementation to slow the signs of brain aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Citrus / Caenorhabditis elegans / Flavanonas / Sirtuina 1 / Longevidad Límite: Animals Idioma: En Revista: Exp Gerontol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Citrus / Caenorhabditis elegans / Flavanonas / Sirtuina 1 / Longevidad Límite: Animals Idioma: En Revista: Exp Gerontol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido