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Adverse effects of the 5-alpha-reductase inhibitor finasteride on Daphnia magna: Endocrine system and lipid metabolism disruption.
Cho, Hyunki; Sung, Si-Eun; Jang, Giup; Esterhuizen, Maranda; Ryu, Chang Seon; Kim, Youngsam; Kim, Young Jun.
Afiliación
  • Cho H; Environmental Safety Group, KIST Europe Forschungsgesellschaft mbH, Saarbrücken 66123, Germany; Department of Pharmacy, Saarland University, Saarbrücken, Germany.
  • Sung SE; Biologische Experimentalphysik, Saarland University, Saarbrücken, Germany.
  • Jang G; MetaDx Laboratory, Seoul, South Korea.
  • Esterhuizen M; University of Helsinki, Ecosystems and Environment Research Programme, Faculty of Biological and Environmental Sciences, Lahti, Finland.
  • Ryu CS; Environmental Safety Group, KIST Europe Forschungsgesellschaft mbH, Saarbrücken 66123, Germany. Electronic address: changryu@kist-europe.de.
  • Kim Y; Environmental Safety Group, KIST Europe Forschungsgesellschaft mbH, Saarbrücken 66123, Germany; Division of Energy & Environment Technology, University of Science & Technology, Daejeon 34113, South Korea. Electronic address: youngsam.kim@kist-europe.de.
  • Kim YJ; Environmental Safety Group, KIST Europe Forschungsgesellschaft mbH, Saarbrücken 66123, Germany; Division of Energy & Environment Technology, University of Science & Technology, Daejeon 34113, South Korea.
Ecotoxicol Environ Saf ; 281: 116606, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38896907
ABSTRACT
Finasteride, a steroid 5-alpha reductase inhibitor, is commonly used for the treatment of benign prostatic hyperplasia and hair loss. However, despite continued use, its environmental implications have not been thoroughly investigated. Thus, we investigated the acute and chronic adverse impacts of finasteride on Daphnia magna, a crucial planktonic crustacean in freshwater ecosystems selected as bioindicator organism for understanding the ecotoxicological effects. Chronic exposure (for 23 days) to finasteride negatively affected development and reproduction, leading to reduced fecundity, delayed first brood, reduced growth, and reduced neonate size. Additionally, acute exposure (< 24 h) caused decreased expression levels of genes crucial for reproduction and development, especially EcR-A/B (ecdysone receptors), Jhe (juvenile hormone esterase), and Vtg2 (vitellogenin), with oxidative stress-related genes. Untargeted lipidomics/metabolomic analyses revealed lipidomic alteration, including 19 upregulated and 4 downregulated enriched lipid ontology categories, and confirmed downregulation of metabolites. Pathway analysis implicated significant effects on metabolic pathways, including the pentose phosphate pathway, histidine metabolism, beta-alanine metabolism, as well as alanine, aspartate, and glutamate metabolism. This comprehensive study unravels the intricate molecular and metabolic responses of D. magna to finasteride exposure, underscoring the multifaceted impacts of this anti-androgenic compound on a keystone species of freshwater ecosystems. The findings emphasize the importance of understanding the environmental repercussions of widely used pharmaceuticals to protect biodiversity in aquatic ecosystems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Finasterida / Daphnia / Metabolismo de los Lípidos / Inhibidores de 5-alfa-Reductasa Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Finasterida / Daphnia / Metabolismo de los Lípidos / Inhibidores de 5-alfa-Reductasa Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos