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Inflammatory Cytokines in Middle Ear Effusion of Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps With or Without NSAID Intolerance.
Suikkila, Anna; Lyly, Annina; Savinko, Terhi; Vento, Seija I; Saarinen, Riitta; Hafrén, Lena.
Afiliación
  • Suikkila A; Department of Otorhinolaryngology-Head and Neck surgery, University of Helsinki and Helsinki University Hospital.
  • Savinko T; Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
  • Vento SI; Department of Otorhinolaryngology-Head and Neck surgery, University of Helsinki and Helsinki University Hospital.
  • Saarinen R; Department of Otorhinolaryngology-Head and Neck surgery, University of Helsinki and Helsinki University Hospital.
  • Hafrén L; Department of Otorhinolaryngology-Head and Neck surgery, University of Helsinki and Helsinki University Hospital.
Otol Neurotol ; 45(7): 765-772, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38896805
ABSTRACT

OBJECTIVE:

To measure the inflammatory cytokines of middle ear effusion (MEE) in otitis media (OM) associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) with or without nonsteroidal anti-inflammatory drug (NSAID) sensitivity to strengthen our assumption that OM is part of the same inflammatory entity. The potential individual differences between MEE inflammatory cytokines could be used in clinical practice for more individual characterization of the inflammation. STUDY

DESIGN:

Case-control study.

SETTING:

Tertiary referral center. PATIENTS Convenience sample of 24 case patients with otitis media with effusion (OME) or chronic otitis media (COM), asthma, and CRSwNP, 14 of whom had NSAID intolerance, and 8 controls with OME but no history of asthma, CRSwNP, or NSAID intolerance. INTERVENTION Diagnostic. MAIN OUTCOME AND

MEASURE:

Inflammatory cytokines including interleukins (IL)-4, IL-5, IL-6, IL-13, and interferon gamma (IFN-γ) in middle ear effusion.

RESULTS:

The MEE mass fractions of IL-5 ( p = 0.003) and IFN-γ ( p = 0.048) were higher among our case patients with OME/COM than among the controls. For IL-4 and IL-13, the mass fractions were also higher among the case patients than the controls, but this difference was not statistically significant ( p = 0.199 and p = 0.617, respectively). We found no difference between the IL-6 mass fractions of the groups. We found notable heterogeneity in individual patients' cytokine levels.

CONCLUSIONS:

According to our findings, OM, when present, should be considered part of the respiratory inflammatory process associated with asthma and CRSwNP. The individual differences in MEE cytokine levels could be useful as biomarkers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Sinusitis / Otitis Media con Derrame / Rinitis / Antiinflamatorios no Esteroideos / Pólipos Nasales / Citocinas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Otol Neurotol Asunto de la revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Sinusitis / Otitis Media con Derrame / Rinitis / Antiinflamatorios no Esteroideos / Pólipos Nasales / Citocinas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Otol Neurotol Asunto de la revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos