Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014-2024) review.

Nagargoje, Amol A; Deshmukh, Tejshri R; Shaikh, Mubarak H; Khedkar, Vijay M; Shingate, Bapurao B

Nagargoje, Amol A; Deshmukh, Tejshri R; Shaikh, Mubarak H; Khedkar, Vijay M; Shingate, Bapurao B.

Afiliación

Nagargoje AA; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Deshmukh TR; Department of Chemistry, Khopoli Municipal Council College, Khopoli, Maharashtra, India.
Shaikh MH; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Khedkar VM; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Shingate BB; Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, Maharashtra, India.

Arch Pharm (Weinheim) ; 357(9): e2400197, 2024 Sep.

Article en En | MEDLINE | ID: mdl-38895952

ABSTRACT

ABSTRACT

Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure-activity relationship (SAR), and in silico molecular docking studies.

Asunto(s)

Antineoplásicos; Curcumina; Simulación del Acoplamiento Molecular; Curcumina/farmacología; Curcumina/química; Curcumina/síntesis química; Curcumina/análogos & derivados; Humanos; Relación Estructura-Actividad; Antineoplásicos/farmacología; Antineoplásicos/química; Antineoplásicos/síntesis química; Neoplasias/tratamiento farmacológico; Animales; Estructura Molecular

Palabras clave

anticancer activity; curcumin; molecular docking study; monocarbonyl analogs of curcumin; structureactivity relationship

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Curcumina / Simulación del Acoplamiento Molecular / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania

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