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The importance of multimodal CT examination in stroke mimics diagnosis: design of prospective observational multicentre study.
Dvorníková, Katerina; Kunesová, Veronika; Ely, Marcela; Ostrý, Svatopluk; Cábal, Martin; Reiser, Martin; Machová, Linda; Pavlínová, Markéta; Kondé, Adéla; Eliás, Pavel; Jonszta, Tomás; Havelka, Jaroslav; Volný, Ondrej; Bar, Michal.
Afiliación
  • Dvorníková K; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.
  • Kunesová V; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia.
  • Ely M; Cerebrovascular research program, International Clinical Research Center, Brno, Czechia.
  • Ostrý S; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.
  • Cábal M; Cerebrovascular research program, International Clinical Research Center, Brno, Czechia.
  • Reiser M; Hospital in Ceské Budejovice A.S., Ceské Budejovice, Czechia.
  • Machová L; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.
  • Pavlínová M; Hospital in Ceské Budejovice A.S., Ceské Budejovice, Czechia.
  • Kondé A; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.
  • Eliás P; Hospital in Ceské Budejovice A.S., Ceské Budejovice, Czechia.
  • Jonszta T; Department of the Deputy Director for Science, Research and Education, University Hospital in Ostrava, Ostrava, Czechia.
  • Havelka J; Department of Applied Mathematics, Faculty of Electrical Engineering and Computer Science, VSB - Technical University of Ostrava, Ostrava, Czechia.
  • Volný O; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia.
  • Bar M; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia.
Front Neurol ; 15: 1365986, 2024.
Article en En | MEDLINE | ID: mdl-38895699
ABSTRACT

Introduction:

Non-contrast computed tomography (CT) and CT angiography are the gold standard in neuroimaging diagnostics in the case of suspected stroke. CT perfusion (CTP) may play an important role in the diagnosis of stroke mimics (SM), but currently, it is not a standard part of the stroke diagnostic procedure. The project is a multicentre prospective observational clinical research focused on refining the diagnostics of stroke and stroke mimics (SM) in hospital care.

Aim:

This study aimed to evaluate the degree of specificity and sensitivity of multimodal CT (NCCT, CTA, and CTP) in the diagnosis of SM versus stroke.

Methodology:

In this study, we will include 3,000 patients consecutively admitted to the comprehensive stroke centres with a diagnosis of suspected stroke. On the basis of clinical parameters and the results of multimodal CT and magnetic resonance imaging (MRI), the diagnosis of stroke and SM will be established. To clarify the significance of the use of the multimodal CT scan, the analysis will include a comparison of the blinded results for each imaging scan performed by radiologists and AI technology and a comparison of the initial and final diagnosis of the enrolled patients. Based on our results, we will compare the economic indicators and costs that would be saved by not providing inadequate treatment to patients with SM.

Conclusion:

The expected outcome is to present an optimised diagnostic procedure that results in a faster and more accurate diagnosis, thereby eliminating the risk of inadequate treatment in patients with SM. Clinical trial registration clinicaltrials.gov, NCT06045455.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurol Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurol Año: 2024 Tipo del documento: Article Pais de publicación: Suiza